DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지현 | ko |
dc.contributor.author | 조정임 | ko |
dc.contributor.author | 조남표 | ko |
dc.contributor.author | 박병현 | ko |
dc.contributor.author | 권강범 | ko |
dc.contributor.author | 노혜원 | ko |
dc.date.accessioned | 2024-03-26T07:00:10Z | - |
dc.date.available | 2024-03-26T07:00:10Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2007-04 | - |
dc.identifier.citation | 동의생리병리학회지, v.21, no.2, pp.468 - 473 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318869 | - |
dc.description.abstract | The antidiabetic effect of Amomum xanthioides(A. xanthioides) extract was investigated. Alloxan caused the hyperglycemia and hypoinsulinemia by a selective destruction of pancreatic β-cell. Pretreatment of mouse with A. xanthioides extract for 2 days prior to alloxan administration completely protected hyperglycemia induced by alloxan. In addition, administration of A. xanthioides extract to alloxan-induced diabetic mouse significantly abolished hyperglycemia, hypoinsulinemia, and, the reduction of size and number of insulin-secreting cells induced by alloxan. Administration of A. xanthioides extract to alloxan-induced diabetic mouse rapidly increased pancreatic Reg gene expression to 7 days, and then decreased. In alloxan-diabetic mouse, Reg gene expression was increased at 3 days after alloxan injection, and sustained until 24 days. The present results indicate that A. xanthioides extract contains potentially effective components exhibiting both protection and treatment of alloxan-induced diabetes. These results suggested that the antidiabetic effect of A. xanthoides extract may be mediated through the regeneration of pancreatic β-cells. | - |
dc.language | Korean | - |
dc.publisher | 한의병리학회 | - |
dc.title | 사인의 항당뇨 작용에 관한 연구 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 468 | - |
dc.citation.endingpage | 473 | - |
dc.citation.publicationname | 동의생리병리학회지 | - |
dc.identifier.kciid | ART001051116 | - |
dc.contributor.localauthor | 박병현 | - |
dc.contributor.nonIdAuthor | 이지현 | - |
dc.contributor.nonIdAuthor | 조정임 | - |
dc.contributor.nonIdAuthor | 조남표 | - |
dc.contributor.nonIdAuthor | 권강범 | - |
dc.contributor.nonIdAuthor | 노혜원 | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | Amomum xanthioides | - |
dc.subject.keywordPlus | alloxan | - |
dc.subject.keywordPlus | antidiabetic effect | - |
dc.subject.keywordPlus | regeneration | - |
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