DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Sehun | ko |
dc.contributor.author | Kim, Jingyu | ko |
dc.contributor.author | Cho, Seong-In | ko |
dc.contributor.author | Kang, Taejoon | ko |
dc.contributor.author | Kim, Sunjoo | ko |
dc.contributor.author | Lim, Eun-Kyung | ko |
dc.contributor.author | Park, Sang-Hee Ko | ko |
dc.date.accessioned | 2023-11-06T05:00:22Z | - |
dc.date.available | 2023-11-06T05:00:22Z | - |
dc.date.created | 2023-11-06 | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | BIOSENSORS & BIOELECTRONICS, v.241 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | http://hdl.handle.net/10203/314284 | - |
dc.description.abstract | The simultaneous infection with a tripledemic-simultaneous infection with influenza A pH1N1 virus (Flu), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and respiratory syncytial virus (RSV)-necessitates the development of accurate and fast multiplex diagnostic tests. The coronavirus disease 2019 (COVID-19) pandemic has emphasized the importance of virus detection. Field-effect transistor (FET)-based immunobiosensors have a short detection time and do not require labeling or polymerase chain reaction. This study demonstrates the rapid, sensitive detection of influenza A pH1N1, SARS-CoV-2, and RSV using a multiplex immunosensor based on a dual-gate oxide semiconductor thin-film transistor (TFT), a type of FET. The dual-gate oxide TFT was modified by adjusting both top and bottom gate insulators to improve capacitive coupling to approximately 120-fold amplification, exhibiting a high pH sensitivity of about 10 V/pH. The dual-gate oxide TFT-based immunosensor detected the target proteins (hemagglutinin (HA) protein of Flu, spike 1 (S1) protein of SARS-CoV-2, and fusion protein of RSV) of each virus, with a limit of detection of approximately 1 fg/mL. Cultured viruses in phosphate-buffered saline or artificial saliva and clinical nasopharynx samples were detected in 1-mu L sample volumes within 60 s. This promising diagnosis could be potentially as point-of-care tests to facilitate a prompt response to future pandemics with high sensitivity and multiplexed detection without pretreatment. | - |
dc.language | English | - |
dc.publisher | ELSEVIER ADVANCED TECHNOLOGY | - |
dc.title | Rapid and simultaneous multiple detection of a tripledemic using a dual-gate oxide semiconductor thin-film transistor-based immunosensor | - |
dc.type | Article | - |
dc.identifier.wosid | 001084738800001 | - |
dc.identifier.scopusid | 2-s2.0-85172033157 | - |
dc.type.rims | ART | - |
dc.citation.volume | 241 | - |
dc.citation.publicationname | BIOSENSORS & BIOELECTRONICS | - |
dc.identifier.doi | 10.1016/j.bios.2023.115700 | - |
dc.contributor.localauthor | Park, Sang-Hee Ko | - |
dc.contributor.nonIdAuthor | Kim, Jingyu | - |
dc.contributor.nonIdAuthor | Kang, Taejoon | - |
dc.contributor.nonIdAuthor | Kim, Sunjoo | - |
dc.contributor.nonIdAuthor | Lim, Eun-Kyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Multiple detection | - |
dc.subject.keywordAuthor | Dual -gate thin-film transistor | - |
dc.subject.keywordAuthor | Tripledemic | - |
dc.subject.keywordAuthor | Point -of -care test | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | SIO2 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.