DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Jinhyeong | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2023-01-12T05:00:09Z | - |
dc.date.available | 2023-01-12T05:00:09Z | - |
dc.date.created | 2022-10-04 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.citation | ACS APPLIED MATERIALS & INTERFACES, v.15, no.1, pp.48 - 56 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/10203/304316 | - |
dc.description.abstract | Minerals in the Earth's crust have contributed to the natural functioning of ecosystems via biogeochemical interactions. Linnaeite is a cobalt sulfide mineral with a cubic spinel structure that promotes charge transfer reactions with its surroundings. Here we report the hidden feature of linnaeite mineral to dissociate Alzheimer's beta-amyloid (A beta) oligomers under near-infrared (NIR) light irradiation. Alzheimer's disease (AD) is a neurodegenerative disorder caused by the abnormal accumulation of self-assembled A beta peptides in the elderly brain. The beta-sheet structured pore- forming A beta oligomer (beta PFO) is the most neurotoxic species exacerbating the symptoms of AD. However, a therapeutic agent that is capable of inactivating beta PFO has not yet been developed. Our microscopic and spectroscopic analysis results have revealed that NIR-excited linnaeite mineral can modulate the structure of beta PFO by inducing oxidative modifications. We have verified that linnaeite mineral is biocompatible with and has a mitigating effect on the neurotoxicity of beta PFO. This study suggests that minerals in nature have potential as drugs to reduce AD pathology. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Linnaeite Mineral for NIR Light-Triggered Disruption of Alzheimer's Pore-Forming A beta Oligomers | - |
dc.type | Article | - |
dc.identifier.wosid | 000837850000001 | - |
dc.identifier.scopusid | 2-s2.0-85136005951 | - |
dc.type.rims | ART | - |
dc.citation.volume | 15 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 48 | - |
dc.citation.endingpage | 56 | - |
dc.citation.publicationname | ACS APPLIED MATERIALS & INTERFACES | - |
dc.identifier.doi | 10.1021/acsami.2c09601 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | minerals | - |
dc.subject.keywordAuthor | linnaeite | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | HYPOTHESIS | - |
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