DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Jinhyeong | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2022-06-06T03:01:24Z | - |
dc.date.available | 2022-06-06T03:01:24Z | - |
dc.date.created | 2022-06-06 | - |
dc.date.created | 2022-06-06 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.8, no.19 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/296811 | - |
dc.description.abstract | The abnormal self-assembly of beta-amyloid (A beta) peptides and their deposition in the brain is a major pathological feature of Alzheimer's disease (AD), the most prevalent chronic neurodegenerative disease affecting nearly 50 million people worldwide. Here, we report a newly discovered function of magnetoelectric nanomaterials for the dissociation of highly stable A beta aggregates under low-frequency magnetic field. We synthesized magnetoelectric BiFeO3-coated CoFe2O4 (BCFO) nanoparticles, which emit excited charge carriers in response to low-frequency magnetic field without generating heat. We demonstrated that the magnetoelectric coupling effect of BCFO nanoparticles successfully dissociates A beta aggregates via water and dissolved oxygen molecules. Our cytotoxicity evaluation confirmed the alleviating effect of magnetoelectrically excited BCFO nanoparticles on A beta-associated toxicity. We found high efficacy of BCFO nanoparticles for the clearance of microsized A beta plaques in ex vivo brain tissues of an AD mouse model. This study shows the potential of magnetoelectric materials for future AD treatment using magnetic field. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Magnetoelectric dissociation of Alzheimer's beta-amyloid aggregates | - |
dc.type | Article | - |
dc.identifier.wosid | 000798002100024 | - |
dc.identifier.scopusid | 2-s2.0-85129940311 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 19 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.abn1675 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ATOMIC-RESOLUTION STRUCTURE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CELLS | - |
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