C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization

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Synthesis of heteroaryl amines has been an important topic in organic chemistry because of their importance in smallmolecule discovery. In particular, 2-aminopyrimidines represent a highly privileged structural motif that is prevalent in bioactive molecules, but a general strategy to introduce the pyrimidine C2-N bonds via direct functionalization is elusive. Here we describe a synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products in situ. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines, opening the new scope of site-selective heteroaryl C-H functionalization. Our method is compatible with a broad range of pyrimidines with sensitive functional groups and can access complex aminopyrimidines with high selectivity.
Publisher
AMER CHEMICAL SOC
Issue Date
2022-02
Language
English
Article Type
Article
Citation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.144, no.7, pp.2885 - 2892

ISSN
0002-7863
DOI
10.1021/jacs.1c13373
URI
http://hdl.handle.net/10203/292829
Appears in Collection
CH-Journal Papers(저널논문)
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