C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization

Cited 3 time in webofscience Cited 0 time in scopus
  • Hit : 66
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorHam, Won Seokko
dc.contributor.authorChoi, Hoonchulko
dc.contributor.authorZhang, Jianboko
dc.contributor.authorKim, Dongwookko
dc.contributor.authorChang, Sukbokko
dc.date.accessioned2022-04-14T06:53:45Z-
dc.date.available2022-04-14T06:53:45Z-
dc.date.created2022-04-05-
dc.date.created2022-04-05-
dc.date.issued2022-02-
dc.identifier.citationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.144, no.7, pp.2885 - 2892-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10203/292829-
dc.description.abstractSynthesis of heteroaryl amines has been an important topic in organic chemistry because of their importance in smallmolecule discovery. In particular, 2-aminopyrimidines represent a highly privileged structural motif that is prevalent in bioactive molecules, but a general strategy to introduce the pyrimidine C2-N bonds via direct functionalization is elusive. Here we describe a synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products in situ. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines, opening the new scope of site-selective heteroaryl C-H functionalization. Our method is compatible with a broad range of pyrimidines with sensitive functional groups and can access complex aminopyrimidines with high selectivity.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.titleC2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization-
dc.typeArticle-
dc.identifier.wosid000765779100009-
dc.identifier.scopusid2-s2.0-85124871667-
dc.type.rimsART-
dc.citation.volume144-
dc.citation.issue7-
dc.citation.beginningpage2885-
dc.citation.endingpage2892-
dc.citation.publicationnameJOURNAL OF THE AMERICAN CHEMICAL SOCIETY-
dc.identifier.doi10.1021/jacs.1c13373-
dc.contributor.localauthorChang, Sukbok-
dc.contributor.nonIdAuthorHam, Won Seok-
dc.contributor.nonIdAuthorZhang, Jianbo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusQUINOLINE N-OXIDES-
dc.subject.keywordPlusC-H-AMINATION-
dc.subject.keywordPlusCATALYZED DIRECT AMINATION-
dc.subject.keywordPlusLATE-STAGE FUNCTIONALIZATION-
dc.subject.keywordPlusMETAL-FREE SYNTHESIS-
dc.subject.keywordPlusONE-STEP CONVERSION-
dc.subject.keywordPlusVISIBLE-LIGHT-
dc.subject.keywordPlusELECTROPHILIC AMINATION-
dc.subject.keywordPlusMILD-
dc.subject.keywordPlusAMIDATION-
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 3 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0