DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, DaeYong | ko |
dc.contributor.author | Ha, JongHoon | ko |
dc.contributor.author | Ahn, Hyomin | ko |
dc.contributor.author | Jeong, Seong Dong | ko |
dc.contributor.author | Jeong, MoonKyoung | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | Yun, Chae-Ok | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.date.accessioned | 2022-02-22T06:44:11Z | - |
dc.date.available | 2022-02-22T06:44:11Z | - |
dc.date.created | 2022-02-22 | - |
dc.date.created | 2022-02-22 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | ACS APPLIED BIO MATERIALS, v.4, no.12, pp.8333 - 8342 | - |
dc.identifier.issn | 2576-6422 | - |
dc.identifier.uri | http://hdl.handle.net/10203/292356 | - |
dc.description.abstract | Immunogenic cell death (ICD) is a key factor for generating antitumor immunity. Endoplasmic reticulum (ER) stress triggers the release of damage-associated molecular patterns (DAMPs), thus inducing immunogenicity. We developed a polypeptide-based K+ ionophore that perturbed ion homeostasis and elicited a prolonged ER stress. The ER stress not only fosters an oxidative environment that activates mitochondria-dependent apoptosis pathways but also drives immune responses by releasing DAMPs. The ionophore suppressed tumor proliferation in vitro and in vivo based on the pro-apoptotic activity and immunogenicity. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Based K+ Ionophore as a Strong Immunogenic Cell Death Inducer for Cancer Immunotherapy | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-85120618514 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 8333 | - |
dc.citation.endingpage | 8342 | - |
dc.citation.publicationname | ACS APPLIED BIO MATERIALS | - |
dc.identifier.doi | 10.1021/acsabm.1c00861 | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Ahn, Hyomin | - |
dc.contributor.nonIdAuthor | Jeong, Seong Dong | - |
dc.contributor.nonIdAuthor | Yun, Chae-Ok | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | potassium ion efflux | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | immunogenic cell death | - |
dc.subject.keywordAuthor | DAMP release | - |
dc.subject.keywordAuthor | dendritic cell maturation | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | ER STRESS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DAMPS | - |
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