Perilla frutescens Leaf Extract Attenuates Vascular Dementia-Associated Memory Deficits, Neuronal Damages, and Microglial Activation

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dc.contributor.authorKang, Hyun-Baeko
dc.contributor.authorKim, Shin-Hyeko
dc.contributor.authorUhm, Sun-Hoko
dc.contributor.authorKim, Do-Kyungko
dc.contributor.authorLee, Nam-Seobko
dc.contributor.authorJeong, Young-Gilko
dc.contributor.authorSung, Nak-Yunko
dc.contributor.authorKim, Dong-Subko
dc.contributor.authorHan, In-Junko
dc.contributor.authorYoo, Young-Choonko
dc.contributor.authorHan, Seung-Yunko
dc.date.accessioned2022-02-08T06:45:28Z-
dc.date.available2022-02-08T06:45:28Z-
dc.date.created2022-02-08-
dc.date.created2022-02-08-
dc.date.created2022-02-08-
dc.date.issued2022-01-
dc.identifier.citationCURRENT ISSUES IN MOLECULAR BIOLOGY, v.44, no.1, pp.257 - 272-
dc.identifier.issn1467-3037-
dc.identifier.urihttp://hdl.handle.net/10203/292138-
dc.description.abstractVascular dementia (VaD) is characterized by a time-dependent memory deficit and essentially combined with evidence of neuroinflammation. Thus, polyphenol-rich natural plants, which possess anti-inflammatory properties, have received much scientific attention. This study investigated whether Perilla frutescens leaf extract (PFL) exerts therapeutic efficacy against VaD. Sprague Dawley rats were divided into five groups: SO, sham-operated and vehicle treatment; OP, operated and vehicle treatment; PFL-L, operated and low-dose (30 mg/kg) PFL treatment; PFL-M, operated and medium-dose (60 mg/kg) PFL treatment; and PFL-H, operated and high-dose (90 mg/kg) PFL treatment. Two-vessel occlusion and hypovolemia (2VO/H) were employed as a surgical model of VaD, and PFL was given orally perioperatively for 23 days. The rats underwent the Y-maze, Barnes maze, and passive avoidance tests and their brains were subjected to histologic studies. The OP group showed VaD-associated memory deficits, hippocampal neuronal death, and microglial activation; however, the PFL-treated groups showed significant attenuations in all of the above parameters. Using lipopolysaccharide (LPS)-stimulated BV-2 cells, a murine microglial cell line, we measured PFL-mediated changes on the production of nitric oxide (NO), TNF-alpha, and IL-6, and the activities of their upstream MAP kinases (MAPKs)/NF kappa B/inducible NO synthase (iNOS). The LPS-induced upregulations of NO, TNF-alpha, and IL-6 production and MAPKs/NF kappa B/iNOS activities were globally and significantly reversed by 12-h pretreatment of PFL. This suggests that PFL can counteract VaD-associated structural and functional deterioration through the attenuation of neuroinflammation.-
dc.languageEnglish-
dc.publisherMDPI-
dc.titlePerilla frutescens Leaf Extract Attenuates Vascular Dementia-Associated Memory Deficits, Neuronal Damages, and Microglial Activation-
dc.typeArticle-
dc.identifier.wosid000747728600001-
dc.identifier.scopusid2-s2.0-85123075335-
dc.type.rimsART-
dc.citation.volume44-
dc.citation.issue1-
dc.citation.beginningpage257-
dc.citation.endingpage272-
dc.citation.publicationnameCURRENT ISSUES IN MOLECULAR BIOLOGY-
dc.identifier.doi10.3390/cimb44010019-
dc.contributor.localauthorKim, Shin-Hye-
dc.contributor.nonIdAuthorKang, Hyun-Bae-
dc.contributor.nonIdAuthorUhm, Sun-Ho-
dc.contributor.nonIdAuthorKim, Do-Kyung-
dc.contributor.nonIdAuthorLee, Nam-Seob-
dc.contributor.nonIdAuthorJeong, Young-Gil-
dc.contributor.nonIdAuthorSung, Nak-Yun-
dc.contributor.nonIdAuthorKim, Dong-Sub-
dc.contributor.nonIdAuthorHan, In-Jun-
dc.contributor.nonIdAuthorYoo, Young-Choon-
dc.contributor.nonIdAuthorHan, Seung-Yun-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorPerilla frutescens-
dc.subject.keywordAuthorvascular dementia-
dc.subject.keywordAuthorhippocampal neuron-
dc.subject.keywordAuthorneuroinflammation-
dc.subject.keywordPlusINFLAMMATORY RESPONSES-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusROSMARINIC ACID-
dc.subject.keywordPlusPOLYPHENOLS-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusNEUROINFLAMMATION-
dc.subject.keywordPlusANTIOXIDANT-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusCYTOKINES-
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