Fabrication and manipulation of stationary microdroplet array and photopolymer array for biological application = 생물학적 응용을 위한 비유동적 미세유체방울 및 광학고분자 배열 생성 및 제어

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Studies bio-systems such as information on human nucleic acid, proteins and cells are being developed focusing on enabling direct diagnoses of individuals’ disease and the analysis of the possibility of disease expression based on gene in line with the modernized society. Since existing biotechnology required analysis conducted through large and expensive equipment, individuals had to use hospitals etc. that had relevant equipment and technology and this worked as great burdens in terms of time and money. As a way to solve this problem, researchers began to develop the lab-on-a-chip (LOC) referred to microfluidic biochips and bioMEMS using MEMS (Micro Electro Mechanical Systems) or NEMS (Nano Electro Mechanical Systems) technology. LOC offers a number of advantages over conventional laboratory tasks. Technologies to fabricate devices to manipulate process and control small volumes of fluids enhanced analytical performance compared to macroscale techniques, low cost, and access a large number of individual experiments per unit time. In addition, the researches of microdroplets in the microfluidic system are emerged as a new and exciting platform for applications within the chemical and biological sciences. Condensed particle to volume ratio in a droplet enables a fast analysis because of the confined density of target molecules released or saved in a droplet. In present day, we developed a simple method for the generation and manipulation of a microdroplet array in a closed system with a novel designed chip called as a ‘Fishbone’ structure. This novel structure was used to make a stationary style microdroplets array in the field of a continuous-flow system by introducing a new type of chip design. In hundreds or thousands of chambers, microdroplets were generated using the surface property and manipulation of carrier fluid. Using this array, we succeeded in performing polymerase chain reaction (PCR) within the hundreds of trapped water droplets. We then generat...
Park, Hyun-Gyuresearcher박현규researcher
한국과학기술원 : 생명화학공학과,
Issue Date
466376/325007  / 020037225

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2011.2, [ ix, 77 ]


biochip; photopolymer; microdroplet; microfluidics; MEMS; 멤스; 바이오칩; 광학고분자; 미세유체방울; 미세유체시스템

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