A latch-type sense amplifier (SA) utilizing adaptive resistance technique is proposed. With adaptively adjusted resistance in a latch path, the proposed SA can compensate for an erroneous voltage drop in bit-lines induced by bit-cell leakage current. The simulation shows that the sense amplifier margin (SM) is improved in the presence of mismatches. The SA test chip is fabricated in a 0.18-μm CMOS technology showing the SM improvement of 6% to 15% at various supply voltages.