DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schiferle, Erik B. | ko |
dc.contributor.author | Cheon, Se Yun | ko |
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | Son, Heehwa G. | ko |
dc.contributor.author | Messerschmidt, Jonathan L. | ko |
dc.contributor.author | Lawrence, Donald P. | ko |
dc.contributor.author | Cohen, Justine V. | ko |
dc.contributor.author | Flaherty, Keith T. | ko |
dc.contributor.author | Moon, James J. | ko |
dc.contributor.author | Lian, Christine G. | ko |
dc.contributor.author | Sullivan, Ryan J. | ko |
dc.contributor.author | Demehri, Shadmehr | ko |
dc.date.accessioned | 2021-07-13T05:50:06Z | - |
dc.date.available | 2021-07-13T05:50:06Z | - |
dc.date.created | 2021-07-13 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.7, no.26 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/286570 | - |
dc.description.abstract | Melanoma and melanocytic nevi harbor shared lineage-specific antigens and oncogenic mutations. Yet, the relationship between the immune system and melanocytic nevi is unclear. Using a patient-derived xenograft (PDX) model, we found that 81.8% of the transplanted nevi underwent spontaneous regression, while peripheral skin remained intact. Nevus-resident CD4(+) T helper 1 cells, which exhibited a massive clonal expansion to melanocyte-specific antigens, were responsible for nevus rejection. Boosting regulatory T cell suppressive function with low-dose exogenous human interleukin-2 injection or treatment with a human leukocyte antigen (HLA) class II-blocking antibody prevented nevus rejection. Notably, mice with rejected nevus PDXs were protected from melanoma tumor growth. We detected a parallel CD4(+) T cell-dominant immunity in clinically regressing melanocytic nevi. These findings reveal a mechanistic explanation for spontaneous nevus regression in humans and posit the activation of nevus-resident CD4(+) effector T cells as a novel strategy for melanoma immunoprevention and treatment. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Rejection of benign melanocytic nevi by nevus-resident CD4(+) T cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000664978800019 | - |
dc.identifier.scopusid | 2-s2.0-85108717177 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 26 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.abg4498 | - |
dc.contributor.localauthor | Ham, Seokjin | - |
dc.contributor.nonIdAuthor | Schiferle, Erik B. | - |
dc.contributor.nonIdAuthor | Cheon, Se Yun | - |
dc.contributor.nonIdAuthor | Son, Heehwa G. | - |
dc.contributor.nonIdAuthor | Messerschmidt, Jonathan L. | - |
dc.contributor.nonIdAuthor | Lawrence, Donald P. | - |
dc.contributor.nonIdAuthor | Cohen, Justine V. | - |
dc.contributor.nonIdAuthor | Flaherty, Keith T. | - |
dc.contributor.nonIdAuthor | Moon, James J. | - |
dc.contributor.nonIdAuthor | Lian, Christine G. | - |
dc.contributor.nonIdAuthor | Sullivan, Ryan J. | - |
dc.contributor.nonIdAuthor | Demehri, Shadmehr | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RNA-SEQ DATA | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | SENESCENCE | - |
dc.subject.keywordPlus | HISTORY | - |
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