Cloning of genomic DNA encoding murine poly(A)-binding protein Ⅱ = 생쥐 Poly(A) 결합 단백질 Ⅱ 유전자의 클로닝

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Formation of the 3``-end is an essential step in almost all eukaryotic messenger RNA syntheses. The genomic DNA clone for poly(A)-binding protein II, which plays a crucial role in poly(A) addition and its length control, was isolated from mouse genomic library using cDNA probe. In order to elucidate the genomic structure of this clone, named mPAB II (murine poly(A)-binding protein II), the total sequence of 8.2 kb was determined. Its sequence shows that the genome of mPAB II consists of 7 exons and 6 introns, and indicates strong homology with that of the bovine PAB II. The predicted amino acid sequence contains one putative RNA-binding domain of the RNP type. Based on the examination of sequence elements at promoter region and CpG islands profile, it is estimated that this housekeeping gene might have a TATA$^{-}$Inr$^{+}$ promoter.
Advisors
Joe, Cheol-O.researcher조철오researcher
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
1997
Identifier
112665/325007 / 000953466
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물과학과, 1997.2, [ v, 40 p. ]

Keywords

Poly(A)-binding protein II; pre-mRNA 3``-end processing; Promoter; 프로모터; 폴리(A) 결합 단백질 II; 초기전사체 3`` 말단 처리

URI
http://hdl.handle.net/10203/28528
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=112665&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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