Behavioral and neural mechanisms of risk/loss aversion and reciprocation in patients with anxiety and depression불안증과 우울증 환자에서 위험/손실 회피와 보답의 행동 및 신경 메커니즘에 대한 연구

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Anxiety and depression are the most prevalent psychiatric disorder in human. In spite of these relativeness, decision making deficits in the patients remain unclear. We aimed to characterize behavioral and neural mechanisms under decision making related to own monetary outcomes only and under decision making related to social aspects as well as own monetary outcomes in patients with anxiety and depression. First, we investigated behavioral characteristics of aversion to risk and loss in patients with the psychiatric disorder and healthy controls. Next, we investigated behavioral characteristics of reciprocation according to confliction level in patients with the psychiatric disorder and healthy controls. In addition, we measured brain activities using fMRI to elucidate neural substrates of the decision making according to the behaviors in non-clinical subjects. We found that the patients had higher loss aversion and risk aversion in loss than the healthy subjects. The patients had correlation between loss aversion and risk aversion in gain, but the healthy subjects did not. In the healthy subjects, the females had higher loss aversion than the males, but the patients had no gender difference in the behaviors. Anxiety and depression scores had positive correlation with loss aversion. Brain regions implicated in subjective values that reported from previous studies were observed again and brain regions related to behavioral choice were observed. We found that the patients had higher reciprocation than the healthy subjects. In the patients, the males had higher reciprocation than the females, but the healthy subjects had no gender difference in the behaviors. Prosociality and Honesty/Humility had positive correlation with reciprocation. Groups divided by incentive delay tasks had different reciprocation according to their sensitivities to social and economic stimuli. Brain regions implicated to each decision phases of reciprocation and the regions related to confliction in reciprocation choice were observed. The present study demonstrated behavioral and neural mechanisms of economic decision making and social decision making between the patients and healthy participants. Our study provides advanced understanding of human decision making and provides insights in to the clinical usage of the behavioral and neuroimaging assessments based on a neuroeconomics framework for the diagnosis and prognosis of psychiatric disorders.
Advisors
Jeong, Jaeseungresearcher정재승researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[xi, 99 p. :]

Keywords

Economic decision making▼aSocial decision making▼aRisk aversion▼aLoss aversion▼aReciprocation▼aAnxiety disorder▼aDepressive disorder; 경제적 의사결정▼a사회적 의사결정▼a위험 회피▼a손실 회피▼a보답▼a불안증▼a우울증

URI
http://hdl.handle.net/10203/283526
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=904422&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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