Tin-nickel sulfide nanocomposite deposited on nickel foam (TNS/NF) displays high electrocatalytic activity toward glucose oxidation. As an enzymeless glucose sensor, the TNS/NF sensing electrode shows a linear range of response from 3 to 5 mM, with a low detection limit of 0.18 mu M signal-to-noise ratio of 3 and high sensitivity of 1622.9 mu A mM(-1) cm(-2). In addition, the proposed sensing electrode shows a fast response time of less than 2 s on glucose addition. The resulting biosensor has high selectivity, excellent reproducibility, and long-term stability for glucose detection. It should be a worthy note; the TNS/NF could be successfully applied in determining glucose in a real blood sample at an applied voltage of 0.5 V.Graphic abstract