Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

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Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1 beta-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1 beta-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2020-07
Language
English
Article Type
Article
Citation

SCIENCE IMMUNOLOGY, v.5, no.49

ISSN
2470-9468
DOI
10.1126/sciimmunol.abd1554
URI
http://hdl.handle.net/10203/275717
Appears in Collection
MSE-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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