DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Seok | ko |
dc.contributor.author | Park, Seongwan | ko |
dc.contributor.author | Jeong, Hye Won | ko |
dc.contributor.author | Ahn, Jin Young | ko |
dc.contributor.author | Choi, Seong Jin | ko |
dc.contributor.author | Lee, Hoyoung | ko |
dc.contributor.author | Choi, Baekgyu | ko |
dc.contributor.author | Nam, Su Kyung | ko |
dc.contributor.author | Sa, Moa | ko |
dc.contributor.author | Kwon, Ji-Soo | ko |
dc.contributor.author | Jeong, Su Jin | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.contributor.author | Park, Sung Ho | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Choi, Jun Yong | ko |
dc.contributor.author | Kim, Sung-Han | ko |
dc.contributor.author | Jung, Inkyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2020-08-05T08:55:19Z | - |
dc.date.available | 2020-08-05T08:55:19Z | - |
dc.date.created | 2020-07-27 | - |
dc.date.created | 2020-07-27 | - |
dc.date.created | 2020-07-27 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | SCIENCE IMMUNOLOGY, v.5, no.49 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | http://hdl.handle.net/10203/275717 | - |
dc.description.abstract | Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1 beta-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1 beta-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 | - |
dc.type | Article | - |
dc.identifier.wosid | 000546994600006 | - |
dc.identifier.scopusid | 2-s2.0-85088204873 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.issue | 49 | - |
dc.citation.publicationname | SCIENCE IMMUNOLOGY | - |
dc.identifier.doi | 10.1126/sciimmunol.abd1554 | - |
dc.contributor.localauthor | Lee, Jeong Seok | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Jung, Inkyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Park, Seongwan | - |
dc.contributor.nonIdAuthor | Jeong, Hye Won | - |
dc.contributor.nonIdAuthor | Ahn, Jin Young | - |
dc.contributor.nonIdAuthor | Choi, Seong Jin | - |
dc.contributor.nonIdAuthor | Lee, Hoyoung | - |
dc.contributor.nonIdAuthor | Choi, Baekgyu | - |
dc.contributor.nonIdAuthor | Nam, Su Kyung | - |
dc.contributor.nonIdAuthor | Jeong, Su Jin | - |
dc.contributor.nonIdAuthor | Park, Sung Ho | - |
dc.contributor.nonIdAuthor | Choi, Jun Yong | - |
dc.contributor.nonIdAuthor | Kim, Sung-Han | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SARS-COV | - |
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