Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis

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Natural products are widely employed in our daily lives as food additives, pharmaceuticals, nutraceuticals, and cosmetic ingredients, among others. However, their supply has often been limited because of low-yield extraction from natural resources such as plants. To overcome this problem, metabolically engineered Escherichia coli has emerged as a cell factory for natural product biosynthesis because of many advantages including the availability of well-established tools and strategies for metabolic engineering and high cell density culture, in addition to its high growth rate. We review state-of-the-art metabolic engineering strategies for enhanced production of natural products in E. coli, together with representative examples. Future challenges and prospects of natural product biosynthesis by engineered E. coli are also discussed.
Publisher
ELSEVIER SCIENCE LONDON
Issue Date
2020-07
Language
English
Article Type
Review
Citation

TRENDS IN BIOTECHNOLOGY, v.38, no.7, pp.745 - 765

ISSN
0167-7799
DOI
10.1016/j.tibtech.2019.11.007
URI
http://hdl.handle.net/10203/275074
Appears in Collection
CBE-Journal Papers(저널논문)
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