Different contributions of somatostatin- and parvalbumin-expressing neurons to flexible representation of task variables in rodent prefrontal cortex

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Neurons in the prefrontal cortex (PFC) are selectively responsive to variables that are relevant to a task at hand. To investigate how different interneuron subtypes contribute to such flexible representation of task variables, we examined discharge characteristics and inactivation effects of somatostatin (SOM)- and parvalbumin (PV)-expressing neurons in the mouse medial PFC during a probabilistic classical conditioning task. SOM neurons showed strong cue-related activity predicting an upcoming reward or punishment, and its inactivation suppressed cuerelated, but not outcome-related, activity of nearby pyramidal neurons. By contrast, PV neurons showed strong outcome- and cue-related responses after outcome delivery, and its inactivation suppressed both cue- and outcome-dependent responses of pyramidal neurons after, but not before, trial outcome. In addition, inactivation of PV, but not SOM, neurons delayed reversal of cue-related responses in neighboring pyramidal neurons when cue-outcome contingency was reversed. These results suggest different contributions of SOM and PV neurons to maintaining significant sensory information and evaluating trial outcome in reference to expected outcome.
Society for Neuroscience
Issue Date

Neuroscience 2018

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BS-Conference Papers(학술회의논문)
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