DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Huijeong | ko |
dc.contributor.author | Kim, Dohoung | ko |
dc.contributor.author | Jung, Min Whan | ko |
dc.date.accessioned | 2020-05-06T01:20:56Z | - |
dc.date.available | 2020-05-06T01:20:56Z | - |
dc.date.created | 2020-04-27 | - |
dc.date.created | 2020-04-27 | - |
dc.date.issued | 2018-11-04 | - |
dc.identifier.citation | Neuroscience 2018 | - |
dc.identifier.uri | http://hdl.handle.net/10203/274060 | - |
dc.description.abstract | Neurons in the prefrontal cortex (PFC) are selectively responsive to variables that are relevant to a task at hand. To investigate how different interneuron subtypes contribute to such flexible representation of task variables, we examined discharge characteristics and inactivation effects of somatostatin (SOM)- and parvalbumin (PV)-expressing neurons in the mouse medial PFC during a probabilistic classical conditioning task. SOM neurons showed strong cue-related activity predicting an upcoming reward or punishment, and its inactivation suppressed cuerelated, but not outcome-related, activity of nearby pyramidal neurons. By contrast, PV neurons showed strong outcome- and cue-related responses after outcome delivery, and its inactivation suppressed both cue- and outcome-dependent responses of pyramidal neurons after, but not before, trial outcome. In addition, inactivation of PV, but not SOM, neurons delayed reversal of cue-related responses in neighboring pyramidal neurons when cue-outcome contingency was reversed. These results suggest different contributions of SOM and PV neurons to maintaining significant sensory information and evaluating trial outcome in reference to expected outcome. | - |
dc.language | English | - |
dc.publisher | Society for Neuroscience | - |
dc.title | Different contributions of somatostatin- and parvalbumin-expressing neurons to flexible representation of task variables in rodent prefrontal cortex | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | Neuroscience 2018 | - |
dc.identifier.conferencecountry | US | - |
dc.identifier.conferencelocation | San Diego, CA | - |
dc.contributor.localauthor | Jung, Min Whan | - |
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