DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, Nelson C. | ko |
dc.contributor.author | Seto, Anita G. | ko |
dc.contributor.author | Kim, Jinkuk | ko |
dc.contributor.author | Kuramochi-Miyagawa, Satomi | ko |
dc.contributor.author | Nakano, Toru | ko |
dc.contributor.author | Bartel, David P. | ko |
dc.contributor.author | Kingston, Robert E. | ko |
dc.date.accessioned | 2020-04-17T02:20:22Z | - |
dc.date.available | 2020-04-17T02:20:22Z | - |
dc.date.created | 2020-04-17 | - |
dc.date.created | 2020-04-17 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | SCIENCE, v.313, no.5785, pp.363 - 367 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/273911 | - |
dc.description.abstract | Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search for candidate mammalian factors for TGS, we purified a complex that contains small RNAs and Riwi, the rat homolog to human Piwi. The RNAs, frequently 29 to 30 nucleotides in length, are called Piwi-interacting RNAs (piRNAs), 94% of which map to 100 defined (<= 101 kb) genomic regions. Within these regions, the piRNAs generally distribute across only one genomic strand or distribute on two strands but in a divergent, nonoverlapping manner. Preparations of piRNA complex ( piRC) contain rRecQ1, which is homologous to qde-3 from Neurospora, a gene implicated in silencing pathways. Piwi has been genetically linked to TGS in flies, and slicer activity cofractionates with the purified complex. These results are consistent with a gene-silencing role for piRC in mammals. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Characterization of the piRNA complex from rat testes | - |
dc.type | Article | - |
dc.identifier.wosid | 000239154300048 | - |
dc.identifier.scopusid | 2-s2.0-33746527679 | - |
dc.type.rims | ART | - |
dc.citation.volume | 313 | - |
dc.citation.issue | 5785 | - |
dc.citation.beginningpage | 363 | - |
dc.citation.endingpage | 367 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.1130164 | - |
dc.contributor.localauthor | Kim, Jinkuk | - |
dc.contributor.nonIdAuthor | Lau, Nelson C. | - |
dc.contributor.nonIdAuthor | Seto, Anita G. | - |
dc.contributor.nonIdAuthor | Kuramochi-Miyagawa, Satomi | - |
dc.contributor.nonIdAuthor | Nakano, Toru | - |
dc.contributor.nonIdAuthor | Bartel, David P. | - |
dc.contributor.nonIdAuthor | Kingston, Robert E. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SMALL RNAS | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | PIWI | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | SPERMATOGENESIS | - |
dc.subject.keywordPlus | HETEROCHROMATIN | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | TETRAHYMENA | - |
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