A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model

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Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized cellular-level observation of the islets in the pancreas in vivo. By spatially separating the pancreas from the bowel movement and physiologic respiration with a metal plate integrated in the imaging window, we successfully tracked the pancreatic islets up to three weeks and visualized the dumbbell-shape transformation from the single islet. This window can be a useful tool for long-term cellular-level visualization of the microstructure in the pancreas.
Publisher
KOREAN DIABETES ASSOC
Issue Date
2020-02
Language
English
Article Type
Article
Citation

DIABETES & METABOLISM JOURNAL, v.44, no.1, pp.193 - 198

ISSN
2233-6079
DOI
10.4093/dmj.2018.0268
URI
http://hdl.handle.net/10203/273526
Appears in Collection
NT-Journal Papers(저널논문)
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