The activation of bystander CD8(+) T cells and their roles in viral infection

Cited 1 time in webofscience Cited 0 time in scopus
  • Hit : 108
  • Download : 2
During viral infections, significant numbers of T cells are activated in a T cell receptor-independent and cytokinedependent manner, a phenomenon referred to as “bystander activation.” Cytokines, including type I interferons, interleukin-18, and interleukin-15, are the most important factors that induce bystander activation of T cells, each of which plays a somewhat different role. Bystander T cells lack specificity for the pathogen, but can nevertheless impact the course of the immune response to the infection. For example, bystander-activated CD8+ T cells can participate in protective immunity by secreting cytokines, such as interferon-γ. They also mediate host injury by exerting cytotoxicity that is facilitated by natural killer cell-activating receptors, such as NKG2D, and cytolytic molecules, such as granzyme B. Interestingly, it has been recently reported that there is a strong association between the cytolytic function of bystander-activated CD8+ T cells and host tissue injury in patients with acute hepatitis A virus infection. The current review addresses the induction of bystander CD8+ T cells, their effector functions, and their potential roles in immunity to infection, immunopathology, and autoimmunity.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2019-12
Language
English
Article Type
Review
Citation

EXPERIMENTAL AND MOLECULAR MEDICINE, v.51, pp.1 - 9

ISSN
1226-3613
DOI
10.1038/s12276-019-0316-1
URI
http://hdl.handle.net/10203/271286
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
112886.pdf(896.49 kB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 1 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0