DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Shin | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2020-01-16T03:20:04Z | - |
dc.date.available | 2020-01-16T03:20:04Z | - |
dc.date.created | 2020-01-15 | - |
dc.date.created | 2020-01-15 | - |
dc.date.created | 2020-01-15 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.51, pp.1 - 9 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/271286 | - |
dc.description.abstract | During viral infections, significant numbers of T cells are activated in a T cell receptor-independent and cytokinedependent manner, a phenomenon referred to as “bystander activation.” Cytokines, including type I interferons, interleukin-18, and interleukin-15, are the most important factors that induce bystander activation of T cells, each of which plays a somewhat different role. Bystander T cells lack specificity for the pathogen, but can nevertheless impact the course of the immune response to the infection. For example, bystander-activated CD8+ T cells can participate in protective immunity by secreting cytokines, such as interferon-γ. They also mediate host injury by exerting cytotoxicity that is facilitated by natural killer cell-activating receptors, such as NKG2D, and cytolytic molecules, such as granzyme B. Interestingly, it has been recently reported that there is a strong association between the cytolytic function of bystander-activated CD8+ T cells and host tissue injury in patients with acute hepatitis A virus infection. The current review addresses the induction of bystander CD8+ T cells, their effector functions, and their potential roles in immunity to infection, immunopathology, and autoimmunity. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The activation of bystander CD8(+) T cells and their roles in viral infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000502859600006 | - |
dc.identifier.scopusid | 2-s2.0-85076336042 | - |
dc.type.rims | ART | - |
dc.citation.volume | 51 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 9 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/s12276-019-0316-1 | - |
dc.identifier.kciid | ART002543171 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Tae-Shin | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | EFFECTOR MECHANISMS | - |
dc.subject.keywordPlus | INFLUENZA INFECTION | - |
dc.subject.keywordPlus | CYTOTOXIC FUNCTION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | COGNATE ANTIGEN | - |
dc.subject.keywordPlus | INNATE-LIKE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | VIRUS | - |
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