The activation of bystander CD8(+) T cells and their roles in viral infection

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dc.contributor.authorKim, Tae-Shinko
dc.contributor.authorShin, Eui-Cheolko
dc.date.accessioned2020-01-16T03:20:04Z-
dc.date.available2020-01-16T03:20:04Z-
dc.date.created2020-01-15-
dc.date.created2020-01-15-
dc.date.issued2019-12-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE, v.51, pp.1 - 9-
dc.identifier.issn1226-3613-
dc.identifier.urihttp://hdl.handle.net/10203/271286-
dc.description.abstractDuring viral infections, significant numbers of T cells are activated in a T cell receptor-independent and cytokinedependent manner, a phenomenon referred to as “bystander activation.” Cytokines, including type I interferons, interleukin-18, and interleukin-15, are the most important factors that induce bystander activation of T cells, each of which plays a somewhat different role. Bystander T cells lack specificity for the pathogen, but can nevertheless impact the course of the immune response to the infection. For example, bystander-activated CD8+ T cells can participate in protective immunity by secreting cytokines, such as interferon-γ. They also mediate host injury by exerting cytotoxicity that is facilitated by natural killer cell-activating receptors, such as NKG2D, and cytolytic molecules, such as granzyme B. Interestingly, it has been recently reported that there is a strong association between the cytolytic function of bystander-activated CD8+ T cells and host tissue injury in patients with acute hepatitis A virus infection. The current review addresses the induction of bystander CD8+ T cells, their effector functions, and their potential roles in immunity to infection, immunopathology, and autoimmunity.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleThe activation of bystander CD8(+) T cells and their roles in viral infection-
dc.typeArticle-
dc.identifier.wosid000502859600006-
dc.identifier.scopusid2-s2.0-85076336042-
dc.type.rimsART-
dc.citation.volume51-
dc.citation.beginningpage1-
dc.citation.endingpage9-
dc.citation.publicationnameEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.identifier.doi10.1038/s12276-019-0316-1-
dc.identifier.kciidART002543171-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.nonIdAuthorKim, Tae-Shin-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordPlusCUTTING EDGE-
dc.subject.keywordPlusIFN-GAMMA-
dc.subject.keywordPlusEFFECTOR MECHANISMS-
dc.subject.keywordPlusINFLUENZA INFECTION-
dc.subject.keywordPlusCYTOTOXIC FUNCTION-
dc.subject.keywordPlusIMMUNE-RESPONSES-
dc.subject.keywordPlusCOGNATE ANTIGEN-
dc.subject.keywordPlusINNATE-LIKE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusVIRUS-
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