Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light

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dc.contributor.authorRuan, Haowenko
dc.contributor.authorJang, Mooseokko
dc.contributor.authorYang, Changhueiko
dc.date.accessioned2019-11-29T03:20:14Z-
dc.date.available2019-11-29T03:20:14Z-
dc.date.created2019-11-29-
dc.date.created2019-11-29-
dc.date.created2019-11-29-
dc.date.issued2015-11-
dc.identifier.citationNATURE COMMUNICATIONS, v.6-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/268698-
dc.description.abstractFocusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of similar to 2 mu m. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleOptical focusing inside scattering media with time-reversed ultrasound microbubble encoded light-
dc.typeArticle-
dc.identifier.wosid000366382800001-
dc.identifier.scopusid2-s2.0-84947907508-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/ncomms9968-
dc.contributor.localauthorJang, Mooseok-
dc.contributor.nonIdAuthorRuan, Haowen-
dc.contributor.nonIdAuthorYang, Changhuei-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDIGITAL PHASE-CONJUGATION-
dc.subject.keywordPlusTURBIDITY SUPPRESSION-
dc.subject.keywordPlusCONTRAST AGENTS-
dc.subject.keywordPlusADAPTED-PERTURBATION-
dc.subject.keywordPlusTRANSMISSION MATRIX-
dc.subject.keywordPlusTISSUE-
dc.subject.keywordPlusSAMPLES-
dc.subject.keywordPlusREGIME-
dc.subject.keywordPlusMODE-
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