DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ruan, Haowen | ko |
dc.contributor.author | Jang, Mooseok | ko |
dc.contributor.author | Yang, Changhuei | ko |
dc.date.accessioned | 2019-11-29T03:20:14Z | - |
dc.date.available | 2019-11-29T03:20:14Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.created | 2019-11-29 | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268698 | - |
dc.description.abstract | Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of similar to 2 mu m. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light | - |
dc.type | Article | - |
dc.identifier.wosid | 000366382800001 | - |
dc.identifier.scopusid | 2-s2.0-84947907508 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms9968 | - |
dc.contributor.localauthor | Jang, Mooseok | - |
dc.contributor.nonIdAuthor | Ruan, Haowen | - |
dc.contributor.nonIdAuthor | Yang, Changhuei | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DIGITAL PHASE-CONJUGATION | - |
dc.subject.keywordPlus | TURBIDITY SUPPRESSION | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | ADAPTED-PERTURBATION | - |
dc.subject.keywordPlus | TRANSMISSION MATRIX | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | SAMPLES | - |
dc.subject.keywordPlus | REGIME | - |
dc.subject.keywordPlus | MODE | - |
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