Immunogenic therapeutic nanoparticles to improve cancer immunotherapy = 종양면역치료를 향상시키기 위한 면역유도 치료 나노입자 개발

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To improve cancer immunotherapy, combination of checkpoint blockade therapy and immunogenic chemotherapy have been administrated in clinical. Immunogenic chemotherapy induce the immunogenic cell death (ICD) of cancer and sensitize the cancer to checkpoint blockade. However, recently, expression of CD47 proteins, which inhibit the phagocytosis of phagocytosis cells like macrophage, have been reported that was counterbalanced with Calreticulin, one of the immunogenic molecules from ICD. In this research, we developed the nanoparticles that loaded CD47 siRNAs and immunogenic cell death inducer drugs. Moreover we assigned the nanoparticles to control the release of each drugs to maximizing the combination effects.
Advisors
Park, Jihoresearcher박지호researcher
Description
한국과학기술원 :바이오및뇌공학부,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학부, 2018.8,[iii, 31 p. :]

Keywords

Cancer immunotherapy▼acheckpoint blockade therapy▼aimmunogenic chemotherapy▼aCD47 proteins▼ananoparticles▼acontrol release; 종암 면역 치료▼a면역체크 포인트 억제제▼a면역 유도 화학 요법 치료▼aCD47 단백질▼a나노 소재▼a방출 조절

URI
http://hdl.handle.net/10203/266162
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828679&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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