Immunogenic therapeutic nanoparticles to improve cancer immunotherapy = 종양면역치료를 향상시키기 위한 면역유도 치료 나노입자 개발

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 190
  • Download : 0
DC FieldValueLanguage
dc.contributor.advisorPark, Jiho-
dc.contributor.advisor박지호-
dc.contributor.authorJang, Seong-Hoon-
dc.date.accessioned2019-09-03T02:40:43Z-
dc.date.available2019-09-03T02:40:43Z-
dc.date.issued2018-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828679&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/266162-
dc.description학위논문(석사) - 한국과학기술원 : 바이오및뇌공학부, 2018.8,[iii, 31 p. :]-
dc.description.abstractTo improve cancer immunotherapy, combination of checkpoint blockade therapy and immunogenic chemotherapy have been administrated in clinical. Immunogenic chemotherapy induce the immunogenic cell death (ICD) of cancer and sensitize the cancer to checkpoint blockade. However, recently, expression of CD47 proteins, which inhibit the phagocytosis of phagocytosis cells like macrophage, have been reported that was counterbalanced with Calreticulin, one of the immunogenic molecules from ICD. In this research, we developed the nanoparticles that loaded CD47 siRNAs and immunogenic cell death inducer drugs. Moreover we assigned the nanoparticles to control the release of each drugs to maximizing the combination effects.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectCancer immunotherapy▼acheckpoint blockade therapy▼aimmunogenic chemotherapy▼aCD47 proteins▼ananoparticles▼acontrol release-
dc.subject종암 면역 치료▼a면역체크 포인트 억제제▼a면역 유도 화학 요법 치료▼aCD47 단백질▼a나노 소재▼a방출 조절-
dc.titleImmunogenic therapeutic nanoparticles to improve cancer immunotherapy = 종양면역치료를 향상시키기 위한 면역유도 치료 나노입자 개발-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :바이오및뇌공학부,-
dc.contributor.alternativeauthor장성훈-
Appears in Collection
BiS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0