DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim Hee Taek | ko |
dc.contributor.author | Khang T.U. | ko |
dc.contributor.author | Baritugo K.-A. | ko |
dc.contributor.author | Hyun S.M. | ko |
dc.contributor.author | Kang K.H. | ko |
dc.contributor.author | Jung S.H. | ko |
dc.contributor.author | Song B.K. | ko |
dc.contributor.author | Park K. | ko |
dc.contributor.author | Oh M.-K. | ko |
dc.contributor.author | Kim G.B. | ko |
dc.contributor.author | Kim, Hyun Uk | ko |
dc.contributor.author | Lee Sang Yup | ko |
dc.contributor.author | Park S.J. | ko |
dc.contributor.author | Joo J.C. | ko |
dc.date.accessioned | 2019-02-20T05:15:03Z | - |
dc.date.available | 2019-02-20T05:15:03Z | - |
dc.date.created | 2019-01-30 | - |
dc.date.created | 2019-01-30 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | METABOLIC ENGINEERING, v.51, pp.99 - 109 | - |
dc.identifier.issn | 1096-7176 | - |
dc.identifier.uri | http://hdl.handle.net/10203/250405 | - |
dc.description.abstract | Corynebacterium glutamicum was metabolically engineered for the production of glutaric acid, a C5 dicarboxylic acid that can be used as platform building block chemical for nylons and plasticizers. C. glutamicum gabT and gabD genes and Pseudomonas putida davT and davD genes encoding 5-aminovalerate transaminase and glutarate semialdehyde dehydrogenase, respectively, were examined in C. glutamicum for the construction of a glutaric acid biosynthesis pathway along with P. putida davB and davA genes encoding lysine 2-monooxygenase and delta-aminovaleramidase, respectively. The glutaric acid biosynthesis pathway constructed in recombinant C. glutamicum was engineered by examining strong synthetic promoters PH30 and PH36, C. glutamicum codon-optimized davTDBA genes, and modification of davB gene with an N-terminal His6-tag to improve the production of glutaric acid. It was found that use of N-terminal His6-tagged DavB was most suitable for the production of glutaric acid from glucose. Fed-batch fermentation using the final engineered C. glutamicum H30_GAHis strain, expressing davTDA genes along with davB fused with His6-tag at N-terminus could produce 24.5 g/L of glutaric acid with low accumulation of L-lysine (1.7 g/L), wherein 5-AVA accumulation was not observed during fermentation. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical | - |
dc.type | Article | - |
dc.identifier.wosid | 000456420200011 | - |
dc.identifier.scopusid | 2-s2.0-85057062236 | - |
dc.type.rims | ART | - |
dc.citation.volume | 51 | - |
dc.citation.beginningpage | 99 | - |
dc.citation.endingpage | 109 | - |
dc.citation.publicationname | METABOLIC ENGINEERING | - |
dc.identifier.doi | 10.1016/j.ymben.2018.08.007 | - |
dc.contributor.localauthor | Kim, Hyun Uk | - |
dc.contributor.localauthor | Lee Sang Yup | - |
dc.contributor.nonIdAuthor | Kim Hee Taek | - |
dc.contributor.nonIdAuthor | Khang T.U. | - |
dc.contributor.nonIdAuthor | Baritugo K.-A. | - |
dc.contributor.nonIdAuthor | Hyun S.M. | - |
dc.contributor.nonIdAuthor | Kang K.H. | - |
dc.contributor.nonIdAuthor | Jung S.H. | - |
dc.contributor.nonIdAuthor | Song B.K. | - |
dc.contributor.nonIdAuthor | Park K. | - |
dc.contributor.nonIdAuthor | Oh M.-K. | - |
dc.contributor.nonIdAuthor | Kim G.B. | - |
dc.contributor.nonIdAuthor | Park S.J. | - |
dc.contributor.nonIdAuthor | Joo J.C. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Glutaric acid | - |
dc.subject.keywordAuthor | L-Lysine | - |
dc.subject.keywordAuthor | Corynebacterium glutamicum | - |
dc.subject.keywordAuthor | davTDBA | - |
dc.subject.keywordAuthor | Codon optimization | - |
dc.subject.keywordAuthor | His(6)-tag | - |
dc.subject.keywordAuthor | Fed-batch fermentation | - |
dc.subject.keywordPlus | BIO-BASED PRODUCTION | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | PSEUDOMONAS-PUTIDA | - |
dc.subject.keywordPlus | LYSINE CATABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | 5-AMINOVALERATE | - |
dc.subject.keywordPlus | DEHYDROGENASE | - |
dc.subject.keywordPlus | BIOTECHNOLOGY | - |
dc.subject.keywordPlus | PATHWAY | - |
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