DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sangmin | ko |
dc.contributor.author | Lee, Tae Yong | ko |
dc.contributor.author | Kim, Dong Jae | ko |
dc.contributor.author | Kim, Bomi | ko |
dc.contributor.author | Kim, Shin-Hyun | ko |
dc.date.accessioned | 2018-11-22T07:08:52Z | - |
dc.date.available | 2018-11-22T07:08:52Z | - |
dc.date.created | 2018-11-19 | - |
dc.date.created | 2018-11-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | CHEMISTRY OF MATERIALS, v.30, no.20, pp.7211 - 7220 | - |
dc.identifier.issn | 0897-4756 | - |
dc.identifier.uri | http://hdl.handle.net/10203/246918 | - |
dc.description.abstract | Microcapsules with regular pore size can provide size-selective permeation, which is promising for immunoisolation of cells, protection of enzymes or catalysts, and development of capsule-type sensors. However, conventional approaches have limited biocompatibility or poor dispersion stability of encapsulants. Here, we suggest a simple yet pragmatic method to produce semipermeable microcapsules using osmotic stress. With a capillary microfluidic device, monodisperse microcapsules with ultrathin polymer membranes are prepared by double-emulsion templating. The microcapsules are subjected to a hypotonic condition, by which water is pumped in imposing a tensile stress on the membrane. The osmotic stress initiates cracks at weak spots. As cracks propagate, the pressure gradually reduces as ions diffuse through them, finally resulting in a finite width of cracks. The final width can be controlled from 5 to 10 nm using an initial osmotic pressure of 230 to 690 kPa, enabling fine adjustment of the cutoff threshold of permeation. This osmotic-pressure-mediated control is highly compatible with delicate biological molecules and colloidal dispersions as no etching chemicals are required to form pores. Taking advantage of this method, we demonstrate a capsule-type molecular sensor based on surface-enhanced Raman scattering that obviates pretreatment of samples because the membrane allows the entrance of small target molecules while blocking the large adhesive proteins. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ENHANCED RAMAN-SPECTROSCOPY | - |
dc.subject | ONE-STEP GENERATION | - |
dc.subject | PHASE-SEPARATION | - |
dc.subject | POLYELECTROLYTE MICROCAPSULES | - |
dc.subject | SEMIPERMEABLE MICROCAPSULES | - |
dc.subject | NANOPARTICLE COLLOIDOSOMES | - |
dc.subject | MICROFLUIDIC FABRICATION | - |
dc.subject | FUNCTIONAL MICROCAPSULES | - |
dc.subject | SELECTIVE PERMEABILITY | - |
dc.subject | CAPSULES | - |
dc.title | Osmotic-Stress-Mediated Control of Membrane Permeability of Polymeric Microcapsules | - |
dc.type | Article | - |
dc.identifier.wosid | 000448752100028 | - |
dc.identifier.scopusid | 2-s2.0-85054922569 | - |
dc.type.rims | ART | - |
dc.citation.volume | 30 | - |
dc.citation.issue | 20 | - |
dc.citation.beginningpage | 7211 | - |
dc.citation.endingpage | 7220 | - |
dc.citation.publicationname | CHEMISTRY OF MATERIALS | - |
dc.identifier.doi | 10.1021/acs.chemmater.8b03230 | - |
dc.contributor.localauthor | Kim, Shin-Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENHANCED RAMAN-SPECTROSCOPY | - |
dc.subject.keywordPlus | ONE-STEP GENERATION | - |
dc.subject.keywordPlus | PHASE-SEPARATION | - |
dc.subject.keywordPlus | POLYELECTROLYTE MICROCAPSULES | - |
dc.subject.keywordPlus | SEMIPERMEABLE MICROCAPSULES | - |
dc.subject.keywordPlus | NANOPARTICLE COLLOIDOSOMES | - |
dc.subject.keywordPlus | MICROFLUIDIC FABRICATION | - |
dc.subject.keywordPlus | FUNCTIONAL MICROCAPSULES | - |
dc.subject.keywordPlus | SELECTIVE PERMEABILITY | - |
dc.subject.keywordPlus | CAPSULES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.