A chiral aluminum solvating agent (CASA) for H-1 NMR chiral analysis of alcohols at low temperature

Abstract

A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for H-1 NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, H-1 NMR measurement at low temperature (-40 to 10 degrees C) was required.