Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Cited 24 time in webofscience Cited 0 time in scopus
  • Hit : 236
  • Download : 0
Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2-C6 platform chemicals using recombinant C. glutamicum.
Publisher
SPRINGER
Issue Date
2018-05
Language
English
Article Type
Review
Citation

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.102, no.9, pp.3915 - 3937

ISSN
0175-7598
DOI
10.1007/s00253-018-8896-6
URI
http://hdl.handle.net/10203/242175
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 24 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0