DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Boyoun | ko |
dc.contributor.author | Brinkmann, Melanie M. | ko |
dc.contributor.author | Spooner, Eric | ko |
dc.contributor.author | Lee, Clarissa C. | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Ploegh, Hidde L. | ko |
dc.date.accessioned | 2018-03-21T02:57:14Z | - |
dc.date.available | 2018-03-21T02:57:14Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.citation | NATURE IMMUNOLOGY, v.9, no.12, pp.1407 - 1414 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240852 | - |
dc.description.abstract | Toll-like receptors (TLRs) activate the innate immune system in response to pathogens. Here we show that TLR9 proteolytic cleavage is a prerequisite for TLR9 signaling. Inhibition of lysosomal proteolysis rendered TLR9 inactive. The carboxy-terminal fragment of TLR9 thus generated included a portion of the TLR9 ectodomain, as well as the transmembrane and cytoplasmic domains. This cleavage fragment bound to the TLR9 ligand CpG DNA and, when expressed in Tlr9(-/-) dendritic cells, restored CpG DNA-induced cytokine production. Although cathepsin L generated the requisite TLR9 cleavage products in a cell-free in vitro system, several proteases influenced TLR9 cleavage in intact cells. Lysosomal proteolysis thus contributes to innate immunity by facilitating specific cleavage of TLR9. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | PATTERN-RECOGNITION | - |
dc.subject | CATHEPSIN-L | - |
dc.subject | PATHWAY | - |
dc.subject | TLR9 | - |
dc.subject | MICE | - |
dc.subject | DNA | - |
dc.subject | INDUCTION | - |
dc.subject | COMPLEXES | - |
dc.subject | MOLECULE | - |
dc.title | Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 | - |
dc.type | Article | - |
dc.identifier.wosid | 000260888700016 | - |
dc.identifier.scopusid | 2-s2.0-56349114913 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1407 | - |
dc.citation.endingpage | 1414 | - |
dc.citation.publicationname | NATURE IMMUNOLOGY | - |
dc.identifier.doi | 10.1038/ni.1669 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Park, Boyoun | - |
dc.contributor.nonIdAuthor | Brinkmann, Melanie M. | - |
dc.contributor.nonIdAuthor | Spooner, Eric | - |
dc.contributor.nonIdAuthor | Lee, Clarissa C. | - |
dc.contributor.nonIdAuthor | Ploegh, Hidde L. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION | - |
dc.subject.keywordPlus | CATHEPSIN-L | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TLR9 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | MOLECULE | - |
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