DC Field | Value | Language |
---|---|---|
dc.contributor.author | Green, Nathaniel M. | ko |
dc.contributor.author | Laws, Amy | ko |
dc.contributor.author | Kiefer, Kerstin | ko |
dc.contributor.author | Busconi, Liliana | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Brinkmann, Melanie M. | ko |
dc.contributor.author | Trail, Erin Hodges | ko |
dc.contributor.author | Yasuda, Kei | ko |
dc.contributor.author | Christensen, Sean R. | ko |
dc.contributor.author | Shlomchik, Mark J. | ko |
dc.contributor.author | Vogel, Stefanie | ko |
dc.contributor.author | Connor, John H. | ko |
dc.contributor.author | Ploegh, Hidde | ko |
dc.contributor.author | Eilat, Dan | ko |
dc.contributor.author | Rifkin, Ian R. | ko |
dc.contributor.author | van Seventer, Jean Maguire | ko |
dc.contributor.author | Marshak-Rothstein, Ann | ko |
dc.date.accessioned | 2018-03-21T02:57:07Z | - |
dc.date.available | 2018-03-21T02:57:07Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v.183, no.3, pp.1569 - 1576 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240848 | - |
dc.description.abstract | Type I IFNs play an important, yet poorly characterized, role in systemic lupus erythematosus. To better understand the interplay between type I IFNs and the activation of autoreactive B cells, we evaluated the effect of type I IFN receptor (IFNAR) deficiency in murine B cell responses to common TLR ligands. In comparison to wild-type B cells, TLR7-stimulated IFNAR(-/-) B cells proliferated significantly less well and did not up-regulate costimulatory molecules. By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to other TLR ligands. These defects were not due to a difference in the distribution of B cell populations or a failure to produce a soluble factor other than a type I IFN. Instead, the compromised response pattern reflected the disruption of an IFN-beta feedback loop and constitutively low expression of TLR7 in the IFNAR1(-/-) B cells. These results highlight subtle differences in the IFN dependence of TLR7 responses compared with other TLR-mediated B cell responses. The Journal of Immunology, 2009, 183: 1569-1576. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | I INTERFERON RECEPTOR | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject | MEDIATED ENHANCEMENT | - |
dc.subject | IMMUNE-COMPLEXES | - |
dc.subject | ALPHA PRODUCTION | - |
dc.subject | MICE | - |
dc.subject | ACTIVATION | - |
dc.subject | DISEASE | - |
dc.title | Murine B Cell Response to TLR7 Ligands Depends on an IFN-beta Feedback Loop | - |
dc.type | Article | - |
dc.identifier.wosid | 000268519500012 | - |
dc.identifier.scopusid | 2-s2.0-68149126174 | - |
dc.type.rims | ART | - |
dc.citation.volume | 183 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 1569 | - |
dc.citation.endingpage | 1576 | - |
dc.citation.publicationname | JOURNAL OF IMMUNOLOGY | - |
dc.identifier.doi | 10.4049/jimmunol.0803899 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Green, Nathaniel M. | - |
dc.contributor.nonIdAuthor | Laws, Amy | - |
dc.contributor.nonIdAuthor | Kiefer, Kerstin | - |
dc.contributor.nonIdAuthor | Busconi, Liliana | - |
dc.contributor.nonIdAuthor | Brinkmann, Melanie M. | - |
dc.contributor.nonIdAuthor | Trail, Erin Hodges | - |
dc.contributor.nonIdAuthor | Yasuda, Kei | - |
dc.contributor.nonIdAuthor | Christensen, Sean R. | - |
dc.contributor.nonIdAuthor | Shlomchik, Mark J. | - |
dc.contributor.nonIdAuthor | Vogel, Stefanie | - |
dc.contributor.nonIdAuthor | Connor, John H. | - |
dc.contributor.nonIdAuthor | Ploegh, Hidde | - |
dc.contributor.nonIdAuthor | Eilat, Dan | - |
dc.contributor.nonIdAuthor | Rifkin, Ian R. | - |
dc.contributor.nonIdAuthor | van Seventer, Jean Maguire | - |
dc.contributor.nonIdAuthor | Marshak-Rothstein, Ann | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | I INTERFERON RECEPTOR | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | MEDIATED ENHANCEMENT | - |
dc.subject.keywordPlus | IMMUNE-COMPLEXES | - |
dc.subject.keywordPlus | ALPHA PRODUCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DISEASE | - |
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