DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bomi | ko |
dc.contributor.author | Lee, Sangmin | ko |
dc.contributor.author | Kim, Shin-Hyun | ko |
dc.date.accessioned | 2018-03-21T02:51:27Z | - |
dc.date.available | 2018-03-21T02:51:27Z | - |
dc.date.created | 2018-03-12 | - |
dc.date.created | 2018-03-12 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | ADVANCED MATERIALS INTERFACES, v.5, no.4 | - |
dc.identifier.issn | 2196-7350 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240727 | - |
dc.description.abstract | Biocompatible microcapsules with a function of pH-triggered release are promising for the site-specific release of bio-actives in the human body. In this work, smart microcapsules with three distinct configurations of membranes are produced to control the rate of pH-triggered release. The microcapsules are prepared with a template of water-in-oil-in-water double-emulsion drops. The oil shells of drops contain two polymers dissolved in an organic solvent: one is a biodegradable polymer selected from poly(lactic acid), poly(lactic-co-glycolic acid), and polycaprolactone, and the other is a pH-responsive cationic polymer. Upon the depletion of organic solvent, two polymers confined in the shell undergo phase separation and double-emulsion drops transform to microcapsules with the solid membrane. Three different configurations of the membranes - spherical, snowman-like, and eyeball-like structures - are exclusively produced according to the selection of biodegradable polymers. Although all the microcapsules release hydrophilic encapsulant loaded in the core when they are subjected to a weakly acidic condition, the release kinetics strongly depends on the configuration of the membrane. Larger surface coverage and thinner membrane of pH-responsive domains result in faster release. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.subject | HIGH ENCAPSULATION EFFICIENCY | - |
dc.subject | PHASE-SEPARATION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | MICROFLUIDIC PRODUCTION | - |
dc.subject | CAPSULES | - |
dc.subject | SHELL | - |
dc.subject | DROPS | - |
dc.subject | MICROPARTICLES | - |
dc.subject | MICROCARRIERS | - |
dc.subject | POLYMERSOMES | - |
dc.title | Double-Emulsion-Templated Anisotropic Microcapsules for pH-Triggered Release | - |
dc.type | Article | - |
dc.identifier.wosid | 000425729300016 | - |
dc.identifier.scopusid | 2-s2.0-85040725748 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | ADVANCED MATERIALS INTERFACES | - |
dc.identifier.doi | 10.1002/admi.201701472 | - |
dc.contributor.localauthor | Kim, Shin-Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | double-emulsion drops | - |
dc.subject.keywordAuthor | microcapsules | - |
dc.subject.keywordAuthor | microfluidics | - |
dc.subject.keywordAuthor | polymer-polymer phase separation | - |
dc.subject.keywordAuthor | smart release | - |
dc.subject.keywordPlus | HIGH ENCAPSULATION EFFICIENCY | - |
dc.subject.keywordPlus | PHASE-SEPARATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | MICROFLUIDIC PRODUCTION | - |
dc.subject.keywordPlus | CAPSULES | - |
dc.subject.keywordPlus | SHELL | - |
dc.subject.keywordPlus | DROPS | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | MICROCARRIERS | - |
dc.subject.keywordPlus | POLYMERSOMES | - |
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