DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Li | ko |
dc.contributor.author | Yang, Yiqiu | ko |
dc.contributor.author | Zheng, Jingbin | ko |
dc.contributor.author | Cai, Guodi | ko |
dc.contributor.author | Lee, Yongwoo | ko |
dc.contributor.author | Du, Jikun | ko |
dc.date.accessioned | 2018-02-21T06:38:53Z | - |
dc.date.available | 2018-02-21T06:38:53Z | - |
dc.date.created | 2018-02-19 | - |
dc.date.created | 2018-02-19 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | PHYTOTHERAPY RESEARCH, v.32, no.2, pp.251 - 258 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | http://hdl.handle.net/10203/240380 | - |
dc.description.abstract | Decursin, the major bioactive component of Angelica gigas Nakai, exhibited neuroprotective properties. Our previous studies showed that decursin conferred neuroprotective effects in PC12 cells induced by Amyloid-beta (A beta)(25-35) via antiapoptosis and antioxidant. In this study, the antiinflammatory effects of decursin against PC12 cells injury stimulated by A beta(25-35) were assessed. Our results demonstrated that decursin suppressed the expression of cyclooxygenase-2 protein and prostaglandin E2 content which was stimulated by A beta(25-35) in PC12 cells. Meanwhile, the nuclear translocation of nuclear factor-kappa B in A beta(25-35)-treated PC12 cells was also inhibited by decursin. In addition, decursin suppressed phosphorylation of the two upstream pathway kinases, p38 and c-Jun N-terminal kinase. Overall, our findings indicate that decursin exerts protective effects against neuroinflammation stimulated by A beta(25-35) in PC12 cells by abolishing cyclooxygenase-2 protein expression through inactivation of nuclear factor-kappa B via the upstream kinases including p38 and c-Jun N-terminal kinase. This work provides a new insight into the pharmacological mode of decursin and should facilitate its therapeutic application in treatment of inflammatory disorders. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | ANGELICA-GIGAS | - |
dc.subject | ANTIINFLAMMATORY THERAPY | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | ACTIVE COMPOUND | - |
dc.subject | IN-VIVO | - |
dc.subject | BRAIN | - |
dc.subject | MECHANISM | - |
dc.subject | MEMORY | - |
dc.title | Decursin attenuates the amyloid-beta-induced inflammatory response in PC12 cells via MAPK and nuclear factor-kappa B pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000424287300006 | - |
dc.identifier.scopusid | 2-s2.0-85036567317 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 251 | - |
dc.citation.endingpage | 258 | - |
dc.citation.publicationname | PHYTOTHERAPY RESEARCH | - |
dc.identifier.doi | 10.1002/ptr.5962 | - |
dc.contributor.localauthor | Du, Jikun | - |
dc.contributor.nonIdAuthor | Li, Li | - |
dc.contributor.nonIdAuthor | Yang, Yiqiu | - |
dc.contributor.nonIdAuthor | Zheng, Jingbin | - |
dc.contributor.nonIdAuthor | Cai, Guodi | - |
dc.contributor.nonIdAuthor | Lee, Yongwoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | amyloid-beta | - |
dc.subject.keywordAuthor | decursin | - |
dc.subject.keywordAuthor | inflammatory | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | ANGELICA-GIGAS | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY THERAPY | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ACTIVE COMPOUND | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MEMORY | - |
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