DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jung-Suk | ko |
dc.contributor.author | Braymer, Joseph J. | ko |
dc.contributor.author | Park, Se Kyung | ko |
dc.contributor.author | Mustafa, Shaik | ko |
dc.contributor.author | Chae, Junghyun | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:25:11Z | - |
dc.date.available | 2018-02-21T06:25:11Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | METALLOMICS, v.3, no.3, pp.284 - 291 | - |
dc.identifier.issn | 1756-5901 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240320 | - |
dc.description.abstract | Metal ions associated with amyloid-beta (A beta) species have been suggested to be involved in neurodegeneration leading to the progression of Alzheimer's disease (AD). The role of metal-involved A beta species in AD neuropathogenesis, however, is not fully elucidated. In order to advance this understanding and contribute to the therapeutic development for AD, the rational structure-based design of small molecules that specifically target metal ions surrounded by A beta species has recently received increased attention. To date, only a few compounds have been fashioned for this purpose. Herein, we report the design strategy, synthesis, characterization, and reactivity of new bifunctional IMPY derivatives K1 and K2. Using UV-vis and high-resolution two-dimensional (2D) NMR spectroscopy, the bifunctionality of K1 and K2 (metal chelation and Ab interaction) was confirmed. These bifunctional IMPY derivatives showed preferential reactivity toward metal-induced A beta aggregation over metal-free conditions in both in vitro inhibition and disaggregation experiments. Taken together, this study provides another example of a bifunctional small molecule framework that can target metal ions associated with A beta species. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-beta aggregation | - |
dc.type | Article | - |
dc.identifier.wosid | 000288126200009 | - |
dc.identifier.scopusid | 2-s2.0-79952522223 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 284 | - |
dc.citation.endingpage | 291 | - |
dc.citation.publicationname | METALLOMICS | - |
dc.identifier.doi | 10.1039/c0mt00077a | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Choi, Jung-Suk | - |
dc.contributor.nonIdAuthor | Braymer, Joseph J. | - |
dc.contributor.nonIdAuthor | Park, Se Kyung | - |
dc.contributor.nonIdAuthor | Mustafa, Shaik | - |
dc.contributor.nonIdAuthor | Chae, Junghyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PROTEIN OLIGOMERS | - |
dc.subject.keywordPlus | BINDING SURFACE | - |
dc.subject.keywordPlus | IMAGING AGENT | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | ZINC | - |
dc.subject.keywordPlus | NMR | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
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