Metal-associated amyloid-beta species in Alzheimer's disease

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dc.contributor.authorPithadia, Amit S.ko
dc.contributor.authorLim, Mi Heeko
dc.date.accessioned2018-02-21T06:24:56Z-
dc.date.available2018-02-21T06:24:56Z-
dc.date.created2018-02-08-
dc.date.created2018-02-08-
dc.date.created2018-02-08-
dc.date.issued2012-04-
dc.identifier.citationCURRENT OPINION IN CHEMICAL BIOLOGY, v.16, no.1-2, pp.67 - 73-
dc.identifier.issn1367-5931-
dc.identifier.urihttp://hdl.handle.net/10203/240310-
dc.description.abstractHighly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (An) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding to A beta could facilitate A beta aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD. The connection between metal-A beta interaction/reactivity and AD development, however, has not been clearly revealed owing to the complexity of the disease. In this review, metal-A beta interaction/reactivity and its relation to neurotoxicity are briefly discussed. Additionally, our review illustrates the recent progress of small molecules, capable of targeting metal-A beta species and modulating their interaction/reactivity, which could offer a promising approach to interrogate their role in AD.-
dc.languageEnglish-
dc.publisherCURRENT BIOLOGY LTD-
dc.titleMetal-associated amyloid-beta species in Alzheimer's disease-
dc.typeArticle-
dc.identifier.wosid000303640400010-
dc.identifier.scopusid2-s2.0-84859651929-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.issue1-2-
dc.citation.beginningpage67-
dc.citation.endingpage73-
dc.citation.publicationnameCURRENT OPINION IN CHEMICAL BIOLOGY-
dc.identifier.doi10.1016/j.cbpa.2012.01.016-
dc.contributor.localauthorLim, Mi Hee-
dc.contributor.nonIdAuthorPithadia, Amit S.-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusA-BETA-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusCOORDINATION-
dc.subject.keywordPlusCOPPER-
dc.subject.keywordPlusHEME-
dc.subject.keywordPlusZINC-
dc.subject.keywordPlusNEUROBIOLOGY-
dc.subject.keywordPlusAGGREGATION-
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