DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pithadia, Amit S. | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:24:56Z | - |
dc.date.available | 2018-02-21T06:24:56Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | CURRENT OPINION IN CHEMICAL BIOLOGY, v.16, no.1-2, pp.67 - 73 | - |
dc.identifier.issn | 1367-5931 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240310 | - |
dc.description.abstract | Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-beta (An) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding to A beta could facilitate A beta aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD. The connection between metal-A beta interaction/reactivity and AD development, however, has not been clearly revealed owing to the complexity of the disease. In this review, metal-A beta interaction/reactivity and its relation to neurotoxicity are briefly discussed. Additionally, our review illustrates the recent progress of small molecules, capable of targeting metal-A beta species and modulating their interaction/reactivity, which could offer a promising approach to interrogate their role in AD. | - |
dc.language | English | - |
dc.publisher | CURRENT BIOLOGY LTD | - |
dc.title | Metal-associated amyloid-beta species in Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000303640400010 | - |
dc.identifier.scopusid | 2-s2.0-84859651929 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 67 | - |
dc.citation.endingpage | 73 | - |
dc.citation.publicationname | CURRENT OPINION IN CHEMICAL BIOLOGY | - |
dc.identifier.doi | 10.1016/j.cbpa.2012.01.016 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Pithadia, Amit S. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | COORDINATION | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | HEME | - |
dc.subject.keywordPlus | ZINC | - |
dc.subject.keywordPlus | NEUROBIOLOGY | - |
dc.subject.keywordPlus | AGGREGATION | - |
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