DC Field | Value | Language |
---|---|---|
dc.contributor.author | Savelieff, MG | ko |
dc.contributor.author | Lee, S | ko |
dc.contributor.author | Liu, YZ | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:24:45Z | - |
dc.date.available | 2018-02-21T06:24:45Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | ACS CHEMICAL BIOLOGY, v.8, no.5, pp.856 - 865 | - |
dc.identifier.issn | 1554-8929 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240303 | - |
dc.description.abstract | Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation of misfolded amyloid-beta (A beta) peptides and hyperphosphorylated tau (ptau) proteins in the brain. Since AD etiology remains unclear, several hypotheses have emerged to elucidate its pathological pathways. The amyloid cascade hypothesis, a leading hypothesis for AD development, advocates A beta as the principal culprit. Additionally, evidence suggests that tau may contribute to AD pathology. A beta and tau have also been shown to impact each other's pathology either directly or indirectly. Furthermore, metal ion dyshomeostasis is associated with these misfolded proteins. Metal interactions with A beta and tau/ptau also influences their aggregation properties and neurotoxicity. Herein, we present current understanding on the roles of A beta, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Untangling Amyloid-beta, Tau, and Metals in Alzheimer's Disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000319720700001 | - |
dc.identifier.scopusid | 2-s2.0-84878034899 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 856 | - |
dc.citation.endingpage | 865 | - |
dc.citation.publicationname | ACS CHEMICAL BIOLOGY | - |
dc.identifier.doi | 10.1021/cb400080f | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Savelieff, MG | - |
dc.contributor.nonIdAuthor | Lee, S | - |
dc.contributor.nonIdAuthor | Liu, YZ | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | NEUROFIBRILLARY TANGLES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISORDERS | - |
dc.subject.keywordPlus | STRUCTURAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | PROTEIN OLIGOMERIZATION | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | PHF-TAU | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.