DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyuck Jin | ko |
dc.contributor.author | Korshavn, Kyle J. | ko |
dc.contributor.author | Kochi, Akiko | ko |
dc.contributor.author | Derrick, Jeffrey S. | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:24:16Z | - |
dc.date.available | 2018-02-21T06:24:16Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | CHEMICAL SOCIETY REVIEWS, v.43, no.19, pp.6672 - 6682 | - |
dc.identifier.issn | 0306-0012 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240295 | - |
dc.description.abstract | Cholesterol and metal ions have been suggested to be associated with the onset and progression of Alzheimer's disease (AD). Moreover, recent findings have demonstrated a potential interconnection between these two factors. For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-beta (A beta) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation. Herein, we briefly discuss the potential involvement of cholesterol and metal ions in AD neuropathogenesis in both individual and interrelated manners. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Cholesterol and metal ions in Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000341974600002 | - |
dc.identifier.scopusid | 2-s2.0-84907200610 | - |
dc.type.rims | ART | - |
dc.citation.volume | 43 | - |
dc.citation.issue | 19 | - |
dc.citation.beginningpage | 6672 | - |
dc.citation.endingpage | 6682 | - |
dc.citation.publicationname | CHEMICAL SOCIETY REVIEWS | - |
dc.identifier.doi | 10.1039/c4cs00005f | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Lee, Hyuck Jin | - |
dc.contributor.nonIdAuthor | Korshavn, Kyle J. | - |
dc.contributor.nonIdAuthor | Kochi, Akiko | - |
dc.contributor.nonIdAuthor | Derrick, Jeffrey S. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | EGG-YOLK | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | ZINC | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | CELLS | - |
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