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A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-beta implicated in Alzheimer's disease

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dc.contributor.authorSavelieff, Masha G.ko
dc.contributor.authorLiu, Yuzhongko
dc.contributor.authorSenthamarai, Russell R. P.ko
dc.contributor.authorKorshavn, Kyle J.ko
dc.contributor.authorLee, Hyuck Jinko
dc.contributor.authorRamamoorthy, Ayyalusamyko
dc.contributor.authorLim, Mi Heeko
dc.date.accessioned2018-02-21T06:24:13Z-
dc.date.available2018-02-21T06:24:13Z-
dc.date.created2018-02-08-
dc.date.created2018-02-08-
dc.date.created2018-02-08-
dc.date.created2018-02-08-
dc.date.issued2014-05-
dc.identifier.citationCHEMICAL COMMUNICATIONS, v.50, no.40, pp.5301 - 5303-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10203/240293-
dc.description.abstractAlzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-beta (A beta) over Zn(II)-A beta.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleA small molecule that displays marked reactivity toward copper- versus zinc-amyloid-beta implicated in Alzheimer's disease-
dc.typeArticle-
dc.identifier.wosid000335011200043-
dc.identifier.scopusid2-s2.0-84899083584-
dc.type.rimsART-
dc.citation.volume50-
dc.citation.issue40-
dc.citation.beginningpage5301-
dc.citation.endingpage5303-
dc.citation.publicationnameCHEMICAL COMMUNICATIONS-
dc.identifier.doi10.1039/c3cc48473d-
dc.contributor.localauthorLim, Mi Hee-
dc.contributor.nonIdAuthorSavelieff, Masha G.-
dc.contributor.nonIdAuthorLiu, Yuzhong-
dc.contributor.nonIdAuthorSenthamarai, Russell R. P.-
dc.contributor.nonIdAuthorKorshavn, Kyle J.-
dc.contributor.nonIdAuthorLee, Hyuck Jin-
dc.contributor.nonIdAuthorRamamoorthy, Ayyalusamy-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDIPHENYLPROPYNONE DERIVATIVES-
dc.subject.keywordPlusMETAL-
dc.subject.keywordPlusAGGREGATION-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusDIPHENYLPROPYNONE DERIVATIVES-
dc.subject.keywordPlusMETAL-
dc.subject.keywordPlusAGGREGATION-
dc.subject.keywordPlusDESIGN-
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CH-Journal Papers(저널논문)
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