DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Jung Seung | ko |
dc.contributor.author | Kang, Myeong-Gyun | ko |
dc.contributor.author | Kang, Juhye | ko |
dc.contributor.author | Park, Sun-Young | ko |
dc.contributor.author | Lee, Shin Jung C. | ko |
dc.contributor.author | Kim, Hyun-Tak | ko |
dc.contributor.author | Seo, Jeong Kon | ko |
dc.contributor.author | Kwon, Oh-Hoon | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.contributor.author | Rhee, Hyun-Woo | ko |
dc.contributor.author | Kwon, Tae-Hyuk | ko |
dc.date.accessioned | 2018-02-21T06:06:05Z | - |
dc.date.available | 2018-02-21T06:06:05Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.138, no.34, pp.10968 - 10977 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240269 | - |
dc.description.abstract | Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (O-1(2)) and superoxide radical (O-2(center dot-)) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct involvement in photodynamic therapy (PDT). have not been revealed. Herein, we report Ir(III) complexes designed for ROS generation through a rational strategy to investigate protein modifications by ROS. The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation (<= 1 J cm(-2)) because of the relatively high O-1(2) quantum yield (> 0.78), even with two photon activation. Furthermore, two types of protein modifications (protein oxidation and photo-cross-linking) involved in PDT were characterized by mass spectrometry. These modifications were generated primarily in the endoplasmic reticulum and mitochondria) producing a significant effect for cancer cell death. Consequently, we present a plausible biologically applicable PDT modality that utilizes rationally designed photoactivatable Ir(III) complexpi. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications | - |
dc.type | Article | - |
dc.identifier.wosid | 000382513300047 | - |
dc.identifier.scopusid | 2-s2.0-84984905544 | - |
dc.type.rims | ART | - |
dc.citation.volume | 138 | - |
dc.citation.issue | 34 | - |
dc.citation.beginningpage | 10968 | - |
dc.citation.endingpage | 10977 | - |
dc.citation.publicationname | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1021/jacs.6b05302 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Nam, Jung Seung | - |
dc.contributor.nonIdAuthor | Kang, Myeong-Gyun | - |
dc.contributor.nonIdAuthor | Kang, Juhye | - |
dc.contributor.nonIdAuthor | Park, Sun-Young | - |
dc.contributor.nonIdAuthor | Lee, Shin Jung C. | - |
dc.contributor.nonIdAuthor | Kim, Hyun-Tak | - |
dc.contributor.nonIdAuthor | Seo, Jeong Kon | - |
dc.contributor.nonIdAuthor | Kwon, Oh-Hoon | - |
dc.contributor.nonIdAuthor | Rhee, Hyun-Woo | - |
dc.contributor.nonIdAuthor | Kwon, Tae-Hyuk | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CYCLOMETALATED IR(III) COMPLEXES | - |
dc.subject.keywordPlus | SINGLET OXYGEN GENERATION | - |
dc.subject.keywordPlus | METHIONINE OXIDATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CANCER-CHEMOTHERAPY | - |
dc.subject.keywordPlus | ANTICANCER AGENTS | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | AGGREGATION | - |
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