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College of Engineering(공과대학)Dept. of Chemical and Biomolecular Engineering(생명화학공학과)CBE-Journal Papers(저널논문)

Metabolic engineering for the microbial production of marine bioactive compounds

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dc.contributor.authorMao, Xiangzhaoko
dc.contributor.authorLiu, Zhenko
dc.contributor.authorSun, Jiananko
dc.contributor.authorLee, Sang Yupko
dc.date.accessioned2018-02-21T05:08:59Z-
dc.date.available2018-02-21T05:08:59Z-
dc.date.created2018-01-22-
dc.date.created2018-01-22-
dc.date.created2018-01-22-
dc.date.issued2017-12-
dc.identifier.citationBIOTECHNOLOGY ADVANCES, v.35, no.8, pp.1004 - 1021-
dc.identifier.issn0734-9750-
dc.identifier.urihttp://hdl.handle.net/10203/239927-
dc.description.abstractMany marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives. (C) 2017 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleMetabolic engineering for the microbial production of marine bioactive compounds-
dc.typeArticle-
dc.identifier.wosid000419410800007-
dc.identifier.scopusid2-s2.0-85014599387-
dc.type.rimsART-
dc.citation.volume35-
dc.citation.issue8-
dc.citation.beginningpage1004-
dc.citation.endingpage1021-
dc.citation.publicationnameBIOTECHNOLOGY ADVANCES-
dc.identifier.doi10.1016/j.biotechadv.2017.03.001-
dc.contributor.localauthorLee, Sang Yup-
dc.contributor.nonIdAuthorLiu, Zhen-
dc.contributor.nonIdAuthorSun, Jianan-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorMarine bioactive compounds-
dc.subject.keywordAuthorMetabolic engineering-
dc.subject.keywordAuthorTerpenoids-
dc.subject.keywordAuthorOmega-3 polyunsaturated fatty acids-
dc.subject.keywordAuthorMarine natural drugs-
dc.subject.keywordAuthorSqualene-
dc.subject.keywordAuthorAstaxanthin-
dc.subject.keywordAuthorDocosahexaenoic acid-
dc.subject.keywordAuthorEicosapentaenoic acid-
dc.subject.keywordPlusPOLYUNSATURATED FATTY-ACIDS-
dc.subject.keywordPlusBIOSYNTHESIS GENE-CLUSTER-
dc.subject.keywordPlusIMPROVE ASTAXANTHIN PRODUCTION-
dc.subject.keywordPlusBETA-CAROTENE HYDROXYLASE-
dc.subject.keywordPlusBACTERIUM METHYLOMONAS SP-
dc.subject.keywordPlusEICOSAPENTAENOIC ACID-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusHETEROLOGOUS EXPRESSION-
dc.subject.keywordPlusSACCHAROMYCES-CEREVISIAE-
dc.subject.keywordPlusHAEMATOCOCCUS-PLUVIALIS-
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