Enzyme-Free Colorimetric Detection of Cu2+ by Utilizing Target-Triggered DNAzymes and Toehold-Mediated DNA Strand Displacement Events

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dc.contributor.authorPark, Yeonkyungko
dc.contributor.authorLee, Chang Yeolko
dc.contributor.authorPark, Ki Sooko
dc.contributor.authorPark, Hyun Gyuko
dc.date.accessioned2018-01-30T05:50:11Z-
dc.date.available2018-01-30T05:50:11Z-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.created2018-01-08-
dc.date.issued2017-12-
dc.identifier.citationCHEMISTRY-A EUROPEAN JOURNAL, v.23, no.68, pp.17379 - 17383-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/10203/239478-
dc.description.abstractA new enzyme-free system for colorimetric Cu2+ detection, which relies on target-triggered DNAzymes and toehold-mediated DNA strand-displacement circuits, is described. The system employs a DNAzyme designed to undergo self-cleavage in the presence of Cu2+ and release a catalyst strand that triggers a sequential toehold-mediated strand displacement reaction. This event leads to the release of a split G-quadruplex DNAzyme strand that is initially caged and inactivated by a blocker strand. A fuel strand is further incorporated for the recycling of the catalyst strand to promote another toehold-mediated strand displacement event, which consequently produces a large number of active split G-quadruplex DNAzymes. By employing this design principle, target Cu2+ was very successfully identified with a detection limit of 1.31nm based on the distinct colorimetric signal developed by the oxidation of 2,2-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid promoted by the peroxidase mimicking activity of the released G-quadruplex DNAzymes. Finally, the practical capability of this sensing system was very successfully demonstrated by its use to reliably determine Cu2+ in tap water.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleEnzyme-Free Colorimetric Detection of Cu2+ by Utilizing Target-Triggered DNAzymes and Toehold-Mediated DNA Strand Displacement Events-
dc.typeArticle-
dc.identifier.wosid000417508800028-
dc.identifier.scopusid2-s2.0-85033730166-
dc.type.rimsART-
dc.citation.volume23-
dc.citation.issue68-
dc.citation.beginningpage17379-
dc.citation.endingpage17383-
dc.citation.publicationnameCHEMISTRY-A EUROPEAN JOURNAL-
dc.identifier.doi10.1002/chem.201704346-
dc.contributor.localauthorPark, Hyun Gyu-
dc.contributor.nonIdAuthorPark, Ki Soo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorcopper-
dc.subject.keywordAuthorDNA-
dc.subject.keywordAuthorDNAzyme-
dc.subject.keywordAuthorG-quadruplexes-
dc.subject.keywordAuthorsensors-
dc.subject.keywordPlusGRAPHENE OXIDE-
dc.subject.keywordPlusULTRASENSITIVE DETECTION-
dc.subject.keywordPlusFLUORESCENT BIOSENSOR-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusNUCLEIC-ACIDS-
dc.subject.keywordPlusMERCURIC IONS-
dc.subject.keywordPlusCOPPER-
dc.subject.keywordPlusSENSITIVITY-
dc.subject.keywordPlusSELECTIVITY-
dc.subject.keywordPlusCIRCUITRY-
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CBE-Journal Papers(저널논문)
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