DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yeonkyung | ko |
dc.contributor.author | Lee, Chang Yeol | ko |
dc.contributor.author | Park, Ki Soo | ko |
dc.contributor.author | Park, Hyun Gyu | ko |
dc.date.accessioned | 2018-01-30T05:50:11Z | - |
dc.date.available | 2018-01-30T05:50:11Z | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.created | 2018-01-08 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | CHEMISTRY-A EUROPEAN JOURNAL, v.23, no.68, pp.17379 - 17383 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/10203/239478 | - |
dc.description.abstract | A new enzyme-free system for colorimetric Cu2+ detection, which relies on target-triggered DNAzymes and toehold-mediated DNA strand-displacement circuits, is described. The system employs a DNAzyme designed to undergo self-cleavage in the presence of Cu2+ and release a catalyst strand that triggers a sequential toehold-mediated strand displacement reaction. This event leads to the release of a split G-quadruplex DNAzyme strand that is initially caged and inactivated by a blocker strand. A fuel strand is further incorporated for the recycling of the catalyst strand to promote another toehold-mediated strand displacement event, which consequently produces a large number of active split G-quadruplex DNAzymes. By employing this design principle, target Cu2+ was very successfully identified with a detection limit of 1.31nm based on the distinct colorimetric signal developed by the oxidation of 2,2-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid promoted by the peroxidase mimicking activity of the released G-quadruplex DNAzymes. Finally, the practical capability of this sensing system was very successfully demonstrated by its use to reliably determine Cu2+ in tap water. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Enzyme-Free Colorimetric Detection of Cu2+ by Utilizing Target-Triggered DNAzymes and Toehold-Mediated DNA Strand Displacement Events | - |
dc.type | Article | - |
dc.identifier.wosid | 000417508800028 | - |
dc.identifier.scopusid | 2-s2.0-85033730166 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 68 | - |
dc.citation.beginningpage | 17379 | - |
dc.citation.endingpage | 17383 | - |
dc.citation.publicationname | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.identifier.doi | 10.1002/chem.201704346 | - |
dc.contributor.localauthor | Park, Hyun Gyu | - |
dc.contributor.nonIdAuthor | Park, Ki Soo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | copper | - |
dc.subject.keywordAuthor | DNA | - |
dc.subject.keywordAuthor | DNAzyme | - |
dc.subject.keywordAuthor | G-quadruplexes | - |
dc.subject.keywordAuthor | sensors | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | ULTRASENSITIVE DETECTION | - |
dc.subject.keywordPlus | FLUORESCENT BIOSENSOR | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | NUCLEIC-ACIDS | - |
dc.subject.keywordPlus | MERCURIC IONS | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | SELECTIVITY | - |
dc.subject.keywordPlus | CIRCUITRY | - |
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