DC Field | Value | Language |
---|---|---|
dc.contributor.author | Le Kim Huyen T | ko |
dc.contributor.author | Jun, Hwiseok | ko |
dc.contributor.author | Kim, JIn Ho | ko |
dc.contributor.author | Park, Keunchil | ko |
dc.contributor.author | Kim, Jee-Seon | ko |
dc.contributor.author | Nam, Yoon Sung | ko |
dc.date.accessioned | 2018-01-30T02:40:05Z | - |
dc.date.available | 2018-01-30T02:40:05Z | - |
dc.date.created | 2017-12-29 | - |
dc.date.created | 2017-12-29 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Biomaterials Research, v.21, no.21 | - |
dc.identifier.issn | 2055-7124 | - |
dc.identifier.uri | http://hdl.handle.net/10203/238164 | - |
dc.description.abstract | Background: Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT). Methods: PG-b-PCL is synthesized by three-step processes: polymerization of ethoxyethyl glycerol ether; ringopening polymerization of ε-caprolactone; and deprotection of the PEEGE block. In vitro cytotoxicity of the polyglycerolated lipiodol nanoemulsions is demonstrated using HeLa ovarian cancer cells. The applicability of the prepared nanoemulsions as a contrast agent for CT imaging is also evaluated using micro-CT. Results: Three compositions of PG-b-PCL with different block lengths are synthesized to prepare nanoemulsions. The polyglycerolated lipiodol nanoemulsions exhibit excellent anti-cancer activities, while placebo nanoemulsions have no significant cytotoxicity under the same condition. Micro-CT imaging of the nanoemulsions confirms the ability of nanoemulsions as a contrast agent. Conclusions: This study suggests that PG-b-PCL is a promising polymeric emulsifier for effective stabilization and surface functionalization of drug delivery nanocarriers for therapeutic and imaging agents. | - |
dc.language | English | - |
dc.publisher | Korean Society for Biomaterials | - |
dc.title | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-85031697062 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 21 | - |
dc.citation.publicationname | Biomaterials Research | - |
dc.identifier.doi | 10.1186/s40824-017-0108-4 | - |
dc.identifier.kciid | ART002302003 | - |
dc.contributor.localauthor | Nam, Yoon Sung | - |
dc.contributor.nonIdAuthor | Kim, JIn Ho | - |
dc.contributor.nonIdAuthor | Park, Keunchil | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Amphiphilic copolymers | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Lipiodol | - |
dc.subject.keywordAuthor | Nanoemulsions | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordAuthor | Polyglycerol | - |
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