Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 249
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorLe Kim Huyen Tko
dc.contributor.authorJun, Hwiseokko
dc.contributor.authorKim, JIn Hoko
dc.contributor.authorPark, Keunchilko
dc.contributor.authorKim, Jee-Seonko
dc.contributor.authorNam, Yoon Sungko
dc.date.accessioned2018-01-30T02:40:05Z-
dc.date.available2018-01-30T02:40:05Z-
dc.date.created2017-12-29-
dc.date.created2017-12-29-
dc.date.issued2017-12-
dc.identifier.citationBiomaterials Research, v.21, no.21-
dc.identifier.issn2055-7124-
dc.identifier.urihttp://hdl.handle.net/10203/238164-
dc.description.abstractBackground: Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT). Methods: PG-b-PCL is synthesized by three-step processes: polymerization of ethoxyethyl glycerol ether; ringopening polymerization of ε-caprolactone; and deprotection of the PEEGE block. In vitro cytotoxicity of the polyglycerolated lipiodol nanoemulsions is demonstrated using HeLa ovarian cancer cells. The applicability of the prepared nanoemulsions as a contrast agent for CT imaging is also evaluated using micro-CT. Results: Three compositions of PG-b-PCL with different block lengths are synthesized to prepare nanoemulsions. The polyglycerolated lipiodol nanoemulsions exhibit excellent anti-cancer activities, while placebo nanoemulsions have no significant cytotoxicity under the same condition. Micro-CT imaging of the nanoemulsions confirms the ability of nanoemulsions as a contrast agent. Conclusions: This study suggests that PG-b-PCL is a promising polymeric emulsifier for effective stabilization and surface functionalization of drug delivery nanocarriers for therapeutic and imaging agents.-
dc.languageEnglish-
dc.publisherKorean Society for Biomaterials-
dc.titleLipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications-
dc.typeArticle-
dc.identifier.scopusid2-s2.0-85031697062-
dc.type.rimsART-
dc.citation.volume21-
dc.citation.issue21-
dc.citation.publicationnameBiomaterials Research-
dc.identifier.doi10.1186/s40824-017-0108-4-
dc.identifier.kciidART002302003-
dc.contributor.localauthorNam, Yoon Sung-
dc.contributor.nonIdAuthorKim, JIn Ho-
dc.contributor.nonIdAuthorPark, Keunchil-
dc.description.isOpenAccessN-
dc.subject.keywordAuthorAmphiphilic copolymers-
dc.subject.keywordAuthorCancer-
dc.subject.keywordAuthorLipiodol-
dc.subject.keywordAuthorNanoemulsions-
dc.subject.keywordAuthorPaclitaxel-
dc.subject.keywordAuthorPolyglycerol-
Appears in Collection
MS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0