CoMAGD: Annotation of Gene-Depression Relations

Abstract

Clinical depression is a mental disorder involving genetics and environmental factors. Although much work studied its genetic causes and numerous candidate genes have consequently been looked into and reported in the biomedical literature, no gene expression changes or mutations regarding depression have yet been adequately collected and analyzed for its full pathophysiology. In this paper, we present a depression-specific annotated corpus for text mining systems that target at providing a concise review of depression-gene relations, as well as capturing complex biological events such as gene expression changes. We describe the annotation scheme and the conducted annotation procedure in detail. We discuss issues regarding proper recognition of depression terms and entity interactions for future approaches to the task. The corpus is available at http://www.biopathway.org/CoMAGD.