DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Jisang | ko |
dc.contributor.author | Rejinold, N. Sanoj | ko |
dc.contributor.author | Lee, DaeYong | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.date.accessioned | 2017-11-08T02:21:23Z | - |
dc.date.available | 2017-11-08T02:21:23Z | - |
dc.date.created | 2017-10-23 | - |
dc.date.created | 2017-10-23 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.264, pp.89 - 101 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226704 | - |
dc.description.abstract | Reactive oxygen species (ROS)- or protease-responsive materials have been utilized as carriers in cancer therapies because ROS and specific proteases are overproduced in cancer cells. Methionine-based polypeptides containing a thioether group are promising candidates due to their ROS-responsiveness which provides a phase transition. Herein, we developed protease-activatable cell-penetrating peptide containing a ROS-responsive methionine, a cell permeable lysine chain, and a matrix metalloproteinase (MMP)-cleavable linker. We designed a poly(L-methionine-block-L-lysine)-PLGLAG-PEG (MLMP) and doxorubicin (DOX) was loaded into the micelle core. The MLMP exhibited MMP-sensitive cleavage and ROS-induced DOX release. Moreover, we confirmed efficient DOX delivery into cancer cells and induction of the apoptotic capability in vitro. In a bio-distribution study, IR-780 dye encapsulated MLMP showed superior tumor targetability with long retention. Furthermore, MLMP (DOX) exhibited outstanding tumor inhibition capability with non-toxicity compared to free DOX, indicating that dual stimuli-MLMP has great potential as an anticancer drug delivery platform. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | GENE DELIVERY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | IN-VIVO | - |
dc.subject | INTRACELLULAR DELIVERY | - |
dc.subject | PCL NANOPARTICLES | - |
dc.subject | EFFICIENT | - |
dc.subject | MICELLES | - |
dc.subject | CONJUGATE | - |
dc.subject | PLATFORM | - |
dc.subject | RELEASE | - |
dc.title | Protease-activatable cell-penetrating peptide possessing ROS-triggered phase transition for enhanced cancer therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000412177500009 | - |
dc.identifier.scopusid | 2-s2.0-85028033940 | - |
dc.type.rims | ART | - |
dc.citation.volume | 264 | - |
dc.citation.beginningpage | 89 | - |
dc.citation.endingpage | 101 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/j.jconrel.2017.08.026 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Activatable cell-penetrating peptide | - |
dc.subject.keywordAuthor | Doxorubicin | - |
dc.subject.keywordAuthor | Matrix metalloproteinase | - |
dc.subject.keywordAuthor | Anticancer drug delivery | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INTRACELLULAR DELIVERY | - |
dc.subject.keywordPlus | PCL NANOPARTICLES | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | CONJUGATE | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | RELEASE | - |
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