Short-chain-length polyhydroxyalkanoates: Synthesis in metabolically engineered Escherichia coli and medical applications

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dc.contributor.authorPark, SJko
dc.contributor.authorChoi, JIko
dc.contributor.authorLee, SangYupko
dc.date.accessioned2011-03-14T09:03:06Z-
dc.date.available2011-03-14T09:03:06Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2005-02-
dc.identifier.citationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.15, no.1, pp.206 - 215-
dc.identifier.issn1017-7825-
dc.identifier.urihttp://hdl.handle.net/10203/22644-
dc.description.abstractPolyhydroxyalkanoates (PHAs) are homo or hetero polyesters of (R)-hydroxyalkanoates accumulated in various microorganisms under growth-limiting condition in the presence of excess carbon source. They have been suggested as biodegradable substitutes for chemically synthesized polymers. Recombinant Escherichia coli is one of the promising host strains for the economical production of PHAs, and has been extensively investigated for the process development. The heterologous PHA biosynthetic pathways have been established through the metabolic engineering and inherent metabolic pathways of E. coli have been redirected to supply PHA precursors. Fermentation strategies for cultivating these recombinant E. coli strains have also been developed for the efficient production of PHAs. Nowadays, short-chain-length (SCL) PHAs are being re-invited due to its improved mechanical properties and possible applications in the biomedical area. In this article, recent advances in the development of metabolically engineered E. coli strains for the enhanced production of SCL-PHAs are reviewed. Also, medical applications of SCL-PHAs are discussed.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherKOREAN SOC MICROBIOLOGY BIOTECHNOLOGY-
dc.subjectHIGH-MOLECULAR-WEIGHT-
dc.subjectALCALIGENES-EUTROPHUS H16-
dc.subjectPSEUDOMONAS SP 61-3-
dc.subjectFED-BATCH CULTURE-
dc.subjectPOLY(3-HYDROXYBUTYRATE) PRODUCTION-
dc.subjectBACTERIAL POLYHYDROXYALKANOATES-
dc.subjectRECOMBINANT STRAINS-
dc.subjectPOLY(4-HYDROXYBUTYRIC ACID)-
dc.subjectMECHANICAL-PROPERTIES-
dc.subjectMICROBIAL SYNTHESIS-
dc.titleShort-chain-length polyhydroxyalkanoates: Synthesis in metabolically engineered Escherichia coli and medical applications-
dc.typeArticle-
dc.identifier.wosid000227309000033-
dc.identifier.scopusid2-s2.0-15044366316-
dc.type.rimsART-
dc.citation.volume15-
dc.citation.issue1-
dc.citation.beginningpage206-
dc.citation.endingpage215-
dc.citation.publicationnameJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, SangYup-
dc.contributor.nonIdAuthorPark, SJ-
dc.contributor.nonIdAuthorChoi, JI-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorshort-chain-length PHA-
dc.subject.keywordAuthorE coli-
dc.subject.keywordAuthormetabolic engineering-
dc.subject.keywordAuthormedical application-
dc.subject.keywordPlusHIGH-MOLECULAR-WEIGHT-
dc.subject.keywordPlusALCALIGENES-EUTROPHUS H16-
dc.subject.keywordPlusPSEUDOMONAS SP 61-3-
dc.subject.keywordPlusFED-BATCH CULTURE-
dc.subject.keywordPlusPOLY(3-HYDROXYBUTYRATE) PRODUCTION-
dc.subject.keywordPlusBACTERIAL POLYHYDROXYALKANOATES-
dc.subject.keywordPlusRECOMBINANT STRAINS-
dc.subject.keywordPlusPOLY(4-HYDROXYBUTYRIC ACID)-
dc.subject.keywordPlusMECHANICAL-PROPERTIES-
dc.subject.keywordPlusMICROBIAL SYNTHESIS-
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