DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, JIN SIK | - |
dc.contributor.author | LEE, SANG YUP | - |
dc.date.accessioned | 2011-03-14T08:31:01Z | - |
dc.date.available | 2011-03-14T08:31:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Journal of Microbiology and Biotechnology, Vol.16, No.5, pp.748-756 | en |
dc.identifier.uri | http://hdl.handle.net/10203/22637 | - |
dc.description.abstract | We propose a genome-scale clustering approach to identify whole genome relationships using the functional groups given by the Kyoto Encyclopedia of Genes and Genomes Orthology (KO) database. The metabolic capabilities of each organism were defined by the number of genes in each functional category. The archaeal, bacterial, and eukaryotic genomes were compared by simultaneously applying a twostep clustering method, comprised of a self-organizing tree algorithm followed by unsupervised hierarchical clustering. The clustering results were consistent with various phenotypic characteristics of the organisms analyzed and, additionally, showed a different aspect of the relationship between genomes that have previously been established through rRNA-based comparisons. The proposed approach to collect and cluster the metabolic functional capabilities of organisms should make it a useful tool in predicting relationships among organisms. | en |
dc.description.sponsorship | This work was supported by grants from the Korean Systems Biology Research Project of the Ministry of Science and Technology and by the Brain Korea 21 Project. Further support by the LG Chem Chair Professorship, Microsoft, and IBM SUR program are appreciated. | en |
dc.language.iso | en_US | en |
dc.publisher | The Korean Society for Applied Microbiology | en |
dc.subject | KEGG | - |
dc.subject | orthology | - |
dc.subject | self-organizing tree algorithm | - |
dc.subject | hierarchical clustering | - |
dc.subject | functional category | - |
dc.subject | gene contents | - |
dc.subject | KEGG | - |
dc.subject | orthology | - |
dc.subject | self-organizing tree algorithm | - |
dc.subject | hierarchical clustering | - |
dc.subject | functional category | - |
dc.subject | gene contents | - |
dc.title | Genomic Tree of Gene Contents Based on Functional Groups of KEGG Orthology | en |
dc.type | Article | en |
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