DSpace at KOASAS
College of Engineering(공과대학)Dept. of Chemical and Biomolecular Engineering(생명화학공학과)CBE-Journal Papers(저널논문)

Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII

Cited 33 time in webofscience Cited 0 time in scopus
  • Hit : 368
  • Download : 0
Export
DC FieldValueLanguage
dc.contributor.authorMusiol-Kroll, Ewa M.ko
dc.contributor.authorZubeil, Florianko
dc.contributor.authorSchafhauser, Thomasko
dc.contributor.authorHaertner, Thomasko
dc.contributor.authorKulik, Andreasko
dc.contributor.authorMcArthur, Johnko
dc.contributor.authorKoryakina, Irinako
dc.contributor.authorWohlleben, Wolfgangko
dc.contributor.authorGrond, Stephanieko
dc.contributor.authorWilliams, Gavin J.ko
dc.contributor.authorLee, Sang Yupko
dc.contributor.authorWeber, Tilmannko
dc.date.accessioned2017-05-08T08:47:40Z-
dc.date.available2017-05-08T08:47:40Z-
dc.date.created2017-04-18-
dc.date.created2017-04-18-
dc.date.created2017-04-18-
dc.date.created2017-04-18-
dc.date.issued2017-03-
dc.identifier.citationACS SYNTHETIC BIOLOGY, v.6, no.3, pp.421 - 427-
dc.identifier.issn2161-5063-
dc.identifier.urihttp://hdl.handle.net/10203/223478-
dc.description.abstractDuring polyketide biosynthesis, acyltransferases (ATs) are the essential gatekeepers which provide the assembly lines with precursors and thus contribute greatly to structural diversity. Previously, we demonstrated that the discrete AT KirCII from the kirromycin antibiotic pathway accesses nonmalonate extender units. Here, we exploit the promiscuity of KirCII to generate new kirromycins with allyl- and propargyl-side chains in vivo, the latter were utilized as educts for further modification by ""click"" chemistry.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.titlePolyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII-
dc.typeArticle-
dc.identifier.wosid000397080300006-
dc.identifier.scopusid2-s2.0-85017588486-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.issue3-
dc.citation.beginningpage421-
dc.citation.endingpage427-
dc.citation.publicationnameACS SYNTHETIC BIOLOGY-
dc.identifier.doi10.1021/acssynbio.6b00341-
dc.contributor.localauthorLee, Sang Yup-
dc.contributor.nonIdAuthorMusiol-Kroll, Ewa M.-
dc.contributor.nonIdAuthorZubeil, Florian-
dc.contributor.nonIdAuthorSchafhauser, Thomas-
dc.contributor.nonIdAuthorHaertner, Thomas-
dc.contributor.nonIdAuthorKulik, Andreas-
dc.contributor.nonIdAuthorMcArthur, John-
dc.contributor.nonIdAuthorKoryakina, Irina-
dc.contributor.nonIdAuthorWohlleben, Wolfgang-
dc.contributor.nonIdAuthorGrond, Stephanie-
dc.contributor.nonIdAuthorWilliams, Gavin J.-
dc.contributor.nonIdAuthorWeber, Tilmann-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorantibiotic-
dc.subject.keywordAuthorkirromycin-
dc.subject.keywordAuthorpolyketide synthase-
dc.subject.keywordAuthortrans-acyltransferase-
dc.subject.keywordAuthorengineering click chemistry-
dc.subject.keywordPlusELONGATION-FACTOR-TU-
dc.subject.keywordPlusPROTEIN-SYNTHESIS SYSTEM-
dc.subject.keywordPlusTRANS-AT PKS-
dc.subject.keywordPlusCOA SYNTHETASES-
dc.subject.keywordPlusEXTENDER UNITS-
dc.subject.keywordPlusKIRROMYCIN-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusSYNTHASE-
dc.subject.keywordPlusANTIBIOTICS-
dc.subject.keywordPlusDOMAIN-
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 33 items in WoS Click to see citing articles in records_button

Display Simple Item Record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


rss_1.0 rss_2.0 atom_1.0