Drug-coated microneedles for rapid and painless local anesthesia

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dc.contributor.authorBaek, Sung-Hyunko
dc.contributor.authorShin, Ju-Hyungko
dc.contributor.authorKim, Yeu-Chunko
dc.date.accessioned2017-05-08T08:45:41Z-
dc.date.available2017-05-08T08:45:41Z-
dc.date.created2017-04-18-
dc.date.created2017-04-18-
dc.date.issued2017-03-
dc.identifier.citationBIOMEDICAL MICRODEVICES, v.19, no.1-
dc.identifier.issn1387-2176-
dc.identifier.urihttp://hdl.handle.net/10203/223446-
dc.description.abstractThis study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 +/- 45.9 mu g of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37 degrees C. Furthermore, the microneedle arrays showed consistent in vitro skin penetration and delivered 200.8 +/- 43.9, 224.2 +/- 39.3, and 244.1 +/- 19.6 mu g of lidocaine into the skin 1, 2, and 5 min after application with a high delivery efficiency of 69, 77, and 84%. Compared to a commercially available topical anesthetic EMLA (R) cream, a 22.0, 13.6, and 14.0-fold higher amount of lidocaine was delivered into the skin. Note, in vitro skin permeation of Lidocaine was also notably enhanced by a 2-minapplication of the lidocaine-coated microneedle arrays. Altogether, these results suggest that the biocompatible lidocaine-coated PLLA microneedle arrays could provide significantly rapid local anesthesia in a painless manner without any of the issues from topical applications or hypodermic injections of local anesthetics.-
dc.languageEnglish-
dc.publisherSPRINGER-
dc.subjectRANDOMIZED CONTROLLED-TRIAL-
dc.subjectTRANSDERMAL DELIVERY-
dc.subjectPOLYMER MICRONEEDLES-
dc.subjectDISSOLVING MICRONEEDLES-
dc.subjectTOPICAL ANESTHESIA-
dc.subjectINJECTION SYSTEM-
dc.subjectEMLA CREAM-
dc.subjectLIDOCAINE-
dc.subjectSKIN-
dc.subjectULTRASOUND-
dc.titleDrug-coated microneedles for rapid and painless local anesthesia-
dc.typeArticle-
dc.identifier.wosid000394970800002-
dc.identifier.scopusid2-s2.0-85009818970-
dc.type.rimsART-
dc.citation.volume19-
dc.citation.issue1-
dc.citation.publicationnameBIOMEDICAL MICRODEVICES-
dc.identifier.doi10.1007/s10544-016-0144-1-
dc.contributor.localauthorKim, Yeu-Chun-
dc.contributor.nonIdAuthorBaek, Sung-Hyun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorTransdermal drug delivery-
dc.subject.keywordAuthorCoated-microneedles-
dc.subject.keywordAuthorLocal anesthesia-
dc.subject.keywordAuthorLidocaine-
dc.subject.keywordAuthorPoly (L-lactide)-
dc.subject.keywordPlusRANDOMIZED CONTROLLED-TRIAL-
dc.subject.keywordPlusTRANSDERMAL DELIVERY-
dc.subject.keywordPlusPOLYMER MICRONEEDLES-
dc.subject.keywordPlusDISSOLVING MICRONEEDLES-
dc.subject.keywordPlusTOPICAL ANESTHESIA-
dc.subject.keywordPlusINJECTION SYSTEM-
dc.subject.keywordPlusEMLA CREAM-
dc.subject.keywordPlusLIDOCAINE-
dc.subject.keywordPlusSKIN-
dc.subject.keywordPlusULTRASOUND-
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