DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Sung-Hyun | ko |
dc.contributor.author | Shin, Ju-Hyung | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.date.accessioned | 2017-05-08T08:45:41Z | - |
dc.date.available | 2017-05-08T08:45:41Z | - |
dc.date.created | 2017-04-18 | - |
dc.date.created | 2017-04-18 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | BIOMEDICAL MICRODEVICES, v.19, no.1 | - |
dc.identifier.issn | 1387-2176 | - |
dc.identifier.uri | http://hdl.handle.net/10203/223446 | - |
dc.description.abstract | This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 +/- 45.9 mu g of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37 degrees C. Furthermore, the microneedle arrays showed consistent in vitro skin penetration and delivered 200.8 +/- 43.9, 224.2 +/- 39.3, and 244.1 +/- 19.6 mu g of lidocaine into the skin 1, 2, and 5 min after application with a high delivery efficiency of 69, 77, and 84%. Compared to a commercially available topical anesthetic EMLA (R) cream, a 22.0, 13.6, and 14.0-fold higher amount of lidocaine was delivered into the skin. Note, in vitro skin permeation of Lidocaine was also notably enhanced by a 2-minapplication of the lidocaine-coated microneedle arrays. Altogether, these results suggest that the biocompatible lidocaine-coated PLLA microneedle arrays could provide significantly rapid local anesthesia in a painless manner without any of the issues from topical applications or hypodermic injections of local anesthetics. | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | TRANSDERMAL DELIVERY | - |
dc.subject | POLYMER MICRONEEDLES | - |
dc.subject | DISSOLVING MICRONEEDLES | - |
dc.subject | TOPICAL ANESTHESIA | - |
dc.subject | INJECTION SYSTEM | - |
dc.subject | EMLA CREAM | - |
dc.subject | LIDOCAINE | - |
dc.subject | SKIN | - |
dc.subject | ULTRASOUND | - |
dc.title | Drug-coated microneedles for rapid and painless local anesthesia | - |
dc.type | Article | - |
dc.identifier.wosid | 000394970800002 | - |
dc.identifier.scopusid | 2-s2.0-85009818970 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | BIOMEDICAL MICRODEVICES | - |
dc.identifier.doi | 10.1007/s10544-016-0144-1 | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Baek, Sung-Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Transdermal drug delivery | - |
dc.subject.keywordAuthor | Coated-microneedles | - |
dc.subject.keywordAuthor | Local anesthesia | - |
dc.subject.keywordAuthor | Lidocaine | - |
dc.subject.keywordAuthor | Poly (L-lactide) | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | TRANSDERMAL DELIVERY | - |
dc.subject.keywordPlus | POLYMER MICRONEEDLES | - |
dc.subject.keywordPlus | DISSOLVING MICRONEEDLES | - |
dc.subject.keywordPlus | TOPICAL ANESTHESIA | - |
dc.subject.keywordPlus | INJECTION SYSTEM | - |
dc.subject.keywordPlus | EMLA CREAM | - |
dc.subject.keywordPlus | LIDOCAINE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | ULTRASOUND | - |
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