DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Min Jun | ko |
dc.contributor.author | Yu, Jeong Heon | ko |
dc.contributor.author | Oh, Mi Hwa | ko |
dc.contributor.author | Nam, Yoon Sung | ko |
dc.contributor.author | Lee, Dong Yun | ko |
dc.date.accessioned | 2017-02-09T08:59:10Z | - |
dc.date.available | 2017-02-09T08:59:10Z | - |
dc.date.created | 2017-02-06 | - |
dc.date.created | 2017-02-06 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.45, pp.404 - 411 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/220448 | - |
dc.description.abstract | Visualization of pancreatic islet can provide important information for diagnosis and monitoring of pancreatic islets. By using phage display technology, here we newly identified four candidate peptide sequences with islet-homing property. In vitro binding assay showed that LSALPRT peptide had stronger affinity with islet cells than other candidates. Then this islet-homing peptide (IHP) was chemically conjugated with TAMRA fluorophore for near infrared (NIR) imaging of islet cells. This TMARA-IHP was strongly bound to islets in vitro, but also to cryo-sectioned slice of pancreas tissue ex vivo. Collectively, it would be a considerable potential as therapeutics or diagnostics in future studies. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | PHAGE DISPLAY | - |
dc.subject | BETA-CELL | - |
dc.subject | TRANSPLANTED ISLETS | - |
dc.subject | IN-VIVO | - |
dc.title | Development of fluorescence-conjugated islet-homing peptide using biopanning for targeted optical imaging of pancreatic islet | - |
dc.type | Article | - |
dc.identifier.wosid | 000391647600051 | - |
dc.identifier.scopusid | 2-s2.0-84998962589 | - |
dc.type.rims | ART | - |
dc.citation.volume | 45 | - |
dc.citation.beginningpage | 404 | - |
dc.citation.endingpage | 411 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jiec.2016.10.009 | - |
dc.contributor.localauthor | Nam, Yoon Sung | - |
dc.contributor.nonIdAuthor | Kim, Min Jun | - |
dc.contributor.nonIdAuthor | Lee, Dong Yun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Islet-homing peptide | - |
dc.subject.keywordAuthor | Pancreatic islet | - |
dc.subject.keywordAuthor | Phage display | - |
dc.subject.keywordAuthor | Biopanning | - |
dc.subject.keywordAuthor | Islet imaging | - |
dc.subject.keywordPlus | PHAGE DISPLAY | - |
dc.subject.keywordPlus | BETA-CELL | - |
dc.subject.keywordPlus | TRANSPLANTED ISLETS | - |
dc.subject.keywordPlus | IN-VIVO | - |
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